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Improving Oral Bioavailability of Curcumin Using Novel Organogel-Based Nanoemulsions.
MedLine Citation:
PMID:  22506728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Curcumin is a natural bioactive compound with many health-promoting benefits. Its low oral bioavailability hurdles its application in functional foods. In the present study, novel organogel-based nanoemulsions have been developed for oral delivery of curcumin and improvement of its bioavailability. Recently developed curcumin organogel was used as the oil phase in the curcumin nanoemulsion formulation. Emulsifier was selected as Tween 20, based on the maximum in vitro bioaccessibility of curcumin in the nanoemulsion. In vitro lipolysis profile revealed that digestion of the nanoemulsion was significantly faster and more complete than the organogel. Permeation experiments on Caco-2 cell monolayers suggested that digestion-absorption was the major absorption mechanism for curcumin in the nanoemulsion. Furthermore, in vivo pharmacokinetics analysis on mice confirmed that the oral bioavailability of curcumin in the nanoemulsion was increased by 9-fold compared with unformulated curcumin. This new formulation method may also be used for curcumin oral delivery in functional foods, dietary supplements and pharmaceutical applications.
Authors:
Hailong Yu; Qingrong Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-16
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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