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Improving the Efficacy and Stability of Coronary Reperfusion Following Thrombolysis: Exploring the Thrombin Hypothesis.
MedLine Citation:
PMID:  10603522     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A major assumption in the treatment of patients with acute myocardial infarction (MI) implies that the speed of coronary arterial reperfusion correlates directly with the overall extent of myocardial salvage, and that the extent of mycardial salvage, in turn, determines the absolute reduction in patient mortality. While a growing experience has made it clear that myocardial salvage-independent (time-independent) mechanisms of benefit also exist, few would argue with the hypothesis that the greatest benefit derived from coronary thrombolysis occurs with early (time-dependent) treatment. Thus, improvements in the efficacy of reperfusion and the stability of reperfusion are likely to have considerable impact on patient outcome.
Authors:
Becker
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  1     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  1995  
Date Detail:
Created Date:  1999-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  133-144     Citation Subset:  -    
Affiliation:
Thrombosis Research Center, University of Massachusetts Medical School, Worcester, MA.
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