| Improvements in quality of life associated with insulin analogue therapies in people with type 2 diabetes: Results from the A(1)chieve observational study. | |
| | |
MedLine Citation:
|
PMID: 22153568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
AIMS: To determine the effects on quality of life after starting insulin with, or switching to, insulin analogue therapies in the 24-week, prospective, non-interventional, observational A(1)chieve study conducted across four continents in people with type 2 diabetes. METHODS: Health-related quality of life (HRQoL) was assessed at baseline and at 24weeks by the validated EQ-5D questionnaire (visual analogue score [VAS] and five dimensions) in 66,726 people who had started using basal insulin detemir, mealtime insulin aspart (with or without a basal insulin) or biphasic insulin aspart 30. RESULTS: For the overall cohort, reported HRQoL increased significantly by 13.8 points from 63.4 points at baseline to 77.2 points at 24weeks (p<0.001) (scale 1-100, 100=best health imaginable). Beginning or changing insulin was associated with a significant increase in HRQoL score (+15.0 points and +11.1 points, respectively), resulting in a similar score at 24weeks in the two populations (77.8 and 75.9 points). Reported HRQoL also increased statistically significantly in people administering any insulin analogue regimen and across all regions, although there were some marked regional differences in reported HRQoL at baseline. CONCLUSION: Compared with baseline scores, beginning insulin with, or switching to, insulin analogue therapies are associated with increased HRQoL. |
| | |
Authors:
|
Siddharth Shah; Alexey Zilov; Rachid Malek; Pradana Soewondo; Ole Bech; Leon Litwak |
Related Documents
:
|
19021698 - Selective cox2 inhibition improves whole body and muscular insulin resistance in fructo... 10070058 - Paracellular glucose transport plays a minor role in the unanesthetized dog. 21553968 - Glycemic control among latinos with type 2 diabetes: the role of social-environmental s... 1799948 - Enhanced rectal absorption of insulin in rabbits from hollow-type suppositories contain... 12212018 - Heuristic model linking contextual processes to self-management in african american adu... 22288848 - Melatonin influences insulin secretion primarily via mt(1) receptors in rat insulinoma... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: 94 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
|
Languages: eng Pagination: 364-70 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Bhatia Hospital, Bombay Mutual Terrace, 534 Sandhurst Bridge, 3rd Floor, Mumbai 400007, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An observational non-interventional study of people with diabetes beginning or changed to insulin an...
Next Document: Comparison and validation of capacitive accelerometers for health care applications.