Document Detail

Improvements in lung function of a pediatric cystic fibrosis population in a developing country.
MedLine Citation:
PMID:  18923789     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To document the change in pulmonary function of a pediatric cystic fibrosis population managed at the Red Cross War Memorial Children's Hospital, Cape Town, South Africa, between January 1999 and December 2006. METHODS: Retrospective review of the medical records and best spirometry results within 3-monthly intervals. RESULTS: A total of 1,139 pulmonary function tests from 79 patients showed a significant improvement over the 8 years studied. When comparing the first quarter of 1999 with the last quarter of 2006, 78 pulmonary function tests were performed on 65 patients with equal patient numbers in both groups and similar in terms of gender, age, age at diagnosis, ethnicity, cystic fibrosis genotype and number of patients colonized with either Staphylococcus aureus or Pseudomonas aeruginosa. In 2006, 15 patients (38.5%) were on azithromycin treatment compared to one (2.6%) patient in 1999 (p = 0.0003). Median (interquartile range) forced expiratory volume in 1 second, forced vital capacity, and average expiratory flow between 25 and 75% of forced vital capacity increased from 61% (51-73), 63% (52-89), and 40% (27-57), predicted in the first quarter of 1999, to 81% (69-100, p = 0.004), 82% (70-98, p = 0.007), and 62% (41-87, p = 0.01), predicted during the last quarter of 2006, respectively. CONCLUSIONS: Pulmonary function tests increased by 20% over 8 years in comparable patient groups. This likely reflects improved care of South African children with cystic fibrosis.
Brenda M Morrow; Andrew C Argent; Heather J Zar; Anthony T R Westwood
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Jornal de pediatria     Volume:  84     ISSN:  1678-4782     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-16     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  403-9     Citation Subset:  IM    
School of Child and Adolescent Health, University of Cape Town (UCT), Cape Town, WC, South Africa.
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MeSH Terms
Cystic Fibrosis / complications,  physiopathology,  therapy*
Developing Countries
Outcome and Process Assessment (Health Care)*
Respiratory Function Tests
Retrospective Studies
Severity of Illness Index
South Africa
Comment In:
J Pediatr (Rio J). 2008 Sep-Oct;84(5):383-5   [PMID:  18923794 ]

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