| Improvements in lung function outcomes in children with cystic fibrosis are associated with better nutrition, fewer chronic pseudomonas aeruginosa infections, and dornase alfa use. | |
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MedLine Citation:
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PMID: 18760423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare lung function and nutritional outcomes in cystic fibrosis (CF) for 2 birth cohorts in our CF center. STUDY DESIGN: Patients with CF born between 1985 and 2000 treated in our CF center before age 5 years were included. The patients were divided into 2 equal birth cohorts for comparison: birth cohort 1 (born between 1985 and 1992) and birth cohort 2 (born between 1993 and 2000). To compare lung function, we used forced expiratory volume in the first second (FEV(1))% predicted and FEV(1)% predicted slope from age 6 to 12 years. We hypothesized that we would find significant improvements in lung function and nutritional outcomes in our patients with CF. RESULTS: The patients born between 1993 and 2000 (birth cohort 2) had better lung function, a slower rate of decline in lung function, and better nutritional outcomes compared with those born between 1985 and 1992 (birth cohort 1). Factors associated with a slower rate of decline in lung function in both groups were a higher baseline body mass index (BMI)%, a slower BMI% rate of decline, absence of chronic Pseudomonas aeruginosa respiratory infection, and initiation of dornase alfa (Pulmozyme) therapy before age 9 years. CONCLUSION: Our results demonstrate dramatically improved lung function and nutritional outcomes in the children with CF in our center. The improvements in lung function outcomes are associated with better nutrition, fewer chronic P aeruginosa infections, and dornase alfa therapy. |
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Authors:
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Gary L McPhail; James D Acton; Matthew C Fenchel; Raouf S Amin; Michael Seid |
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Publication Detail:
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Type: Journal Article Date: 2008-08-29 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 153 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-18 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 752-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary Medicine, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Mass Index Child Child, Preschool Chronic Disease Cohort Studies Cystic Fibrosis / complications*, physiopathology, therapy* Deoxyribonuclease I / therapeutic use* Female Growth Humans Longitudinal Studies Male Maximal Expiratory Flow Rate Nutritional Support* Predictive Value of Tests Pseudomonas Infections / complications*, prevention & control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 3.1.21.1/DNASE1 protein, human; EC 3.1.21.1/Deoxyribonuclease I |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2008 Dec;153(6):733-5
[PMID:
19014811
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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