| Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies. | |
| | |
MedLine Citation:
|
PMID: 17335819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a period of 10 years. DESIGN: Retrospective study. SETTING: University-affiliated assisted reproductive technology program. PATIENT(S): Women undergoing oocyte donation (10,537 cycles) between 1995 and 2005. INTERVENTION(S): Ovarian stimulation and oocyte retrieval in donors. Embryo transfer performed in recipients after endometrial preparation. MAIN OUTCOME MEASURE(S): Outcome parameters and cumulative PRs were calculated and compared in relation to indication, age, and origin of sperm used. RESULT(S): Overall PR, implantation rate, clinical PR, and miscarriage rate per embryo transfer performed were 54.9%, 27%, 50.3%, and 19%, respectively. Ongoing PR per transfer was 40.2%, and twin and high-order multiple PRs were 39% and 6%, respectively. Mean number of embryos transferred was reduced from 3.6 +/- 0.8 to 1.9 +/- 0.3, implantation rate improved from 16.7% to 38.3%, and ongoing PR improved from 31% to 44.3%. Cumulative PRs did not differ significantly among different indications for oocyte donation, age groups, or origin of sperm used for oocyte insemination. Overall cumulative PRs after three and five cycles were calculated as 87% and 96.8%, respectively. CONCLUSION(S): Significant improvements in outcome parameters were achieved within 10 years. Similar cumulative PRs were observed regardless of recipient age, indication for oocyte donation, or sperm origin. |
| | |
Authors:
|
Erdal Budak; Nicolas Garrido; Sergio Reis Soares; Marco Antonio Barreto Melo; Marcos Meseguer; Antonio Pellicer; José Remohí |
Related Documents
:
|
3382609 - The treatment of normospermic infertility by gamete intrafallopian transfer (gift). 11529359 - Correlation between human follicular diameter and oocyte recovery, metaphase ii oocytes... 8893679 - Prospective controlled randomized study of in vitro fertilization versus intracytoplasm... 17227619 - Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis. 16799739 - Correlation between number of retrieved oocytes and pregnancy rate after in vitro ferti... 8166199 - Autoantibody profiles and immunoglobulin levels as predictors of in vitro fertilization... 6365599 - Comparison of the operating microscope and loupe for microsurgical tubal anastomosis: a... 20197639 - Effects of krn633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosi... 8090389 - Safety of the new quinolones in pregnancy. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2007-02-28 |
Journal Detail:
|
Title: Fertility and sterility Volume: 88 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-13 Completed Date: 2007-09-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
|
Languages: eng Pagination: 342-9 Citation Subset: IM |
Affiliation:
|
Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Distribution Embryo Implantation* Female Humans Male Middle Aged Oocyte Donation / methods, trends* Pregnancy Pregnancy Rate / trends* Pregnancy, Multiple* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndro...
Next Document: Increased plasma visfatin concentrations in women with polycystic ovary syndrome.