Document Detail

Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome.
MedLine Citation:
PMID:  9860246     Owner:  NLM     Status:  MEDLINE    
We report a case of hyperimmunoglobulin E syndrome (HIE) complicated by neutrophil deficiency which was successfully treated with oral administration of disodium cromoglycate. A 48-year-old Japanese man with HIE developed Streptococcus pneumoniae meningitis. Laboratory tests after the meningitis revealed persistent neutropenia (300-800/mm3) and defects of phagocytosis and bacterial killing by neutrophils. Administration of disodium cromoglycate was started, and neutrophil counts gradually increased to 1200-1600/mm3. The impaired neutrophil activities returned to normal. The patient improved clinically; during the 2-year treatment, he had only two brief episodes of the common cold. Disodium cromoglycate may have potential clinical use in the treatment of cases of HIE even with neutrophil deficiency.
K Kojima; Y Inoue; Y Katayama; M Kataoka; K Sunami; S Fukuda; T Sezaki; E Omoto; M Harada
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Allergy     Volume:  53     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-25     Completed Date:  1999-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1101-3     Citation Subset:  IM    
Department of Medicine, National Okayama Hospital, Japan.
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MeSH Terms
Cromolyn Sodium / therapeutic use*
Hematologic Agents / therapeutic use*
Job's Syndrome / drug therapy*
Meningitis, Bacterial / complications,  microbiology
Middle Aged
Neutropenia / drug therapy,  etiology
Neutrophils / drug effects*,  physiology
Phagocytosis / drug effects*,  physiology
Pulmonary Ventilation / drug effects
Respiratory Burst / drug effects*
Streptococcus pneumoniae
Reg. No./Substance:
0/Hematologic Agents; 15826-37-6/Cromolyn Sodium

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