| Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome. | |
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MedLine Citation:
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PMID: 9860246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of hyperimmunoglobulin E syndrome (HIE) complicated by neutrophil deficiency which was successfully treated with oral administration of disodium cromoglycate. A 48-year-old Japanese man with HIE developed Streptococcus pneumoniae meningitis. Laboratory tests after the meningitis revealed persistent neutropenia (300-800/mm3) and defects of phagocytosis and bacterial killing by neutrophils. Administration of disodium cromoglycate was started, and neutrophil counts gradually increased to 1200-1600/mm3. The impaired neutrophil activities returned to normal. The patient improved clinically; during the 2-year treatment, he had only two brief episodes of the common cold. Disodium cromoglycate may have potential clinical use in the treatment of cases of HIE even with neutrophil deficiency. |
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Authors:
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K Kojima; Y Inoue; Y Katayama; M Kataoka; K Sunami; S Fukuda; T Sezaki; E Omoto; M Harada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Allergy Volume: 53 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-02-25 Completed Date: 1999-02-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 1101-3 Citation Subset: IM |
Affiliation:
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Department of Medicine, National Okayama Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cromolyn Sodium
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therapeutic use* Hematologic Agents / therapeutic use* Humans Job's Syndrome / drug therapy* Male Meningitis, Bacterial / complications, microbiology Middle Aged Neutropenia / drug therapy, etiology Neutrophils / drug effects*, physiology Phagocytosis / drug effects*, physiology Pulmonary Ventilation / drug effects Respiratory Burst / drug effects* Streptococcus pneumoniae |
| Chemical | |
Reg. No./Substance:
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0/Hematologic Agents; 15826-37-6/Cromolyn Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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