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Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes.
MedLine Citation:
PMID:  22344966     Owner:  NLM     Status:  Publisher    
BACKGROUND: Both vitamin D deficiency and inflammation have been linked to cardiovascular disease (CVD), the major cause of death in diabetes. In this study, the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on systemic inflammatory biomarkers in subjects with type 2 diabetes (T2D) were investigated. SUBJECTS AND METHODS: In this 12-week randomized controlled clinical trial (RCT), T2D subjects received either plain doogh (PD; containing 170 mg calcium and no detectable vitamin D/250 mL, n(1)  = 50) or vitamin D3-fortified doogh (FD; containing 170 mg calcium and 500 IU/250 mL, n(2)  = 50) twice a day. Glycemic status, body fat mass (FM) and systemic inflammatory biomarkers including serum hsCRP, serum amyloid A (SAA), interleukin(IL)-2, IL-6, IL-10 and tumor necrosis factor (TNF)-α were evaluated at the beginning and after the intervention. Data were expressed as either mean ± SD or median (interquartile range [IQR]) whenever they had either normal or non-normal distribution, respectively. RESULTS: In the FD group, compared to the PD group, a significant increase in serum 25(OH)D was accompanied by significant changes in TNF-α (-57.9 (-264.6) vs. +106.3 (683.2), p = 0.044), IL-6 (-6.3 (-69.2), p = 0.002), hsCRP (-0.39 (-1.50) vs. +0.8 (1.52), p < 0.001), SAA (-14.2 ± 44.5 vs. +5.6 ± 37.5 mg/L, p = 0.022) and IL-10 (+38.7 ± 157.0 vs. -51.9 ± 165.2 ng/L, p = 0.013). The between-group differences of hsCRP, SAA and IL-6 changes remained significant even after controlling for changes QUICKI (p < 0.001, p < 0.001 and p = 0.009 respectively). CONCLUSIONS: Improvement of vitamin D status of T2D subjects resulted in amelioration of the systemic inflammatory markers. This may have preventive implications against CVD and other diabetic complications. Copyright © 2012 John Wiley & Sons, Ltd.
Sakineh Shab-Bidar; Tirang R Neyestani; Abolghassem Djazayery; Mohammad-Reza Eshraghian; Anahita Houshiarrad; Ali Kalayi; Nastaran Shariatzadeh; Niloufar Khalaji; A'azam Gharavi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-17
Journal Detail:
Title:  Diabetes/metabolism research and reviews     Volume:  -     ISSN:  1520-7560     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883450     Medline TA:  Diabetes Metab Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
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