Document Detail

Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial.
MedLine Citation:
PMID:  19142978     Owner:  NLM     Status:  MEDLINE    
In a randomly allocated, double-blind, placebo-controlled, cross-over design, 50 infertile patients were treated for 1 month with placebo or a combination of l-arginine aspartate and Pycnogenol (Prelox). Semen samples were examined at 4 week intervals according to WHO criteria. Treatment with Prelox increased significantly the semen volume, concentration of spermatozoa, percentage of motile spermatozoa and percentage of spermatozoa with normal morphology compared with placebo. The placebo had no influence on the parameters of seminological analysis. Intake of Pycnogenol for 1 month improved the fertility index to normal values. After treatment, the fertility index decreased again to infertile status. No unwanted effects were reported. Prelox seems to be a promising alternative to treat patients with mild infertility.
R Stanislavov; V Nikolova; P Rohdewald
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  23     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-03     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Copyright Information:
(c) 2009 John Wiley & Sons, Ltd.
Medical University Sofia, Faculty of Medicine, Department of Obstetrics and Gynecology, Sofia, Bulgaria.
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MeSH Terms
Arginine / therapeutic use
Aspartic Acid / therapeutic use
Cross-Over Studies
Double-Blind Method
Flavonoids / therapeutic use*
Infertility, Male / drug therapy*
Middle Aged
Semen Analysis*
Sperm Motility / drug effects
Reg. No./Substance:
0/Flavonoids; 0/pycnogenols; 56-84-8/Aspartic Acid; 74-79-3/Arginine; 7675-83-4/arginine aspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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