Document Detail

Improvement of reflux symptoms 3 years after cure of Helicobacter pylori infection: a case-controlled study in the Japanese population.
MedLine Citation:
PMID:  12165028     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Development of reflux esophagitis is one of the adverse effects that cause concern in relation to curative treatment of Helicobacter pylori infection. However, recent studies present a rather negative association between curative treatment and development of reflux esophagitis or reflux symptoms. Therefore, this issue has remained controversial. Accordingly, we investigated the long-term adverse effects of H. pylori eradication treatment in special reference to development of reflux symptoms. PATIENTS AND METHODS: We conducted a case controlled study by mailing structured questionnaires on past (before curative treatment or 3 years previously) and current status. A case was an endoscopically confirmed peptic ulcer patient with confirmed cure of the infection after eradication treatment 3 years previously and a control was one who had not undergone the eradication treatment during the same period. We studied 241 pairs who matched for age, gender, and type of ulcer disease (GU, DU or GDU). Of these pairs, 81.3% were male and the mean age was 52.6 +/- 9.6 year (range 23-76). RESULTS: The rates of patients with improved reflux symptoms in the case and control groups were 65.4% and 30.4%, respectively, with the rate being significantly greater in the case group. On the contrary, the rates of those with worsened reflux symptoms were similar (5.1% and 7.6%). Regarding general events, the rate of patients with decreased frequency of hospital visits and of those who regularly used antiacid medications were significantly decreased in the case group. Furthermore, the case group experienced significantly fewer hospital admissions for various diseases in this 3-year period. However, a significantly greater number of case group patients than control subjects gained weight. CONCLUSION: Reflux symptoms as well as general well-being were significantly improved after cure of H. pylori infection.
Hiroto Miwa; Yuriko Sugiyama; Toshifumi Ohkusa; Akihiko Kurosawa; Mariko Hojo; Tetsuji Yokoyama; Tsutomu Hamada; Hisashi Basyuda; Nobuhiro Sato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Helicobacter     Volume:  7     ISSN:  1083-4389     ISO Abbreviation:  Helicobacter     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-07     Completed Date:  2002-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9605411     Medline TA:  Helicobacter     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan.
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MeSH Terms
Amoxicillin / therapeutic use
Anti-Bacterial Agents / therapeutic use
Case-Control Studies
Clarithromycin / therapeutic use
Drug Therapy, Combination
Esophagitis, Peptic / physiopathology*
Helicobacter Infections / complications*,  drug therapy*,  microbiology
Helicobacter pylori / drug effects*
Middle Aged
Proton Pumps / antagonists & inhibitors,  therapeutic use
Severity of Illness Index
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Proton Pumps; 26787-78-0/Amoxicillin; 81103-11-9/Clarithromycin

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