Document Detail

Improvement of plasma quality as raw material for factor VIII:C concentrates. Storage of whole blood and plasma and interindividual plasma levels of fibrinopeptide A.
MedLine Citation:
PMID:  6414186     Owner:  NLM     Status:  MEDLINE    
Blood collected into different anticoagulants was stored in small tubes at +4 degrees C for up to 26 h. Seven blood coagulation analyses were performed under standardized conditions. High yield and stability of factor VIII:C were found for ACD and CPD-adenine. No changes could be found in the other six parameters tested. Whole blood in blood bags could be stored for 2-4 h at +4 degrees C with maximal yield of F VIII:C, with blood stored overnight the recovery was 65%. In plasma F VIII:C was stable for at least 2 h at room temperature. F VIIIR:Ag and F VIIIR:RCoF were stable in both whole blood and plasma. No activation by plasmin as measured by B beta 15-42 could be demonstrated. The initial FPA levels, reflecting thrombin activation, in the donated blood differed individually and in some blood bags very high concentrations were found. The levels of FPA were not correlated to the time for collection of a bag of blood.
G Carlebjörk; M Blombäck; O Akerblom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vox sanguinis     Volume:  45     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  233-42     Citation Subset:  IM    
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MeSH Terms
Anticoagulants / pharmacology
Antigens / analysis*
Blood Preservation*
Factor VIII / analysis,  immunology*
Fibrinogen / analysis*
Fibrinopeptide A / analysis*
von Willebrand Factor
Reg. No./Substance:
0/Anticoagulants; 0/Antigens; 0/von Willebrand Factor; 25422-31-5/Fibrinopeptide A; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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