| Improvement of perfusion flow in the isolated rat liver under the influence of streptase. Autohistoradiographic aspects of 125I-labelled fibrinogen deposition. | |
| | |
MedLine Citation:
|
PMID: 580749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The dynamics of the fibrinoplastic process were studied in rat isolated liver, perfused in normothermia with a synthetical medium. For the autohistoradiographical study, 125I-labelled fibrinogen was added to the perfusing medium. The historadiograms obtained suggest that the main link in the rise of trans-hepatic vascular resistance is thickening of the fibrin muff of the sinusoids. Consequent reduction of the capillary permeability determines favourable conditions for stasis and massive precipitation of fibrinogen under the form of fibrin thrombi into the intrahepatic vessels. Streptase addition to the perfusion medium prevents the intervention of these mechanisms during the studied period. |
| | |
Authors:
|
C Duca; S Duca; Z Uray; A T Bogdan; A Suciu; R Lezeu; E Angi |
Related Documents
:
|
9849619 - Oxygen consumption and biosynthetic function in perfused liver from rats at different s... 6870929 - Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the me... 7439339 - Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid. 8098909 - Catabolism of cysteine, cystine, cysteinesulfinate, and otc by isolated perfused rat hi... 1897249 - The uptake of oestrone from the lumen of the isolated perfused rat gut. 1649989 - Oxygen-dependent erythropoietin production by the isolated perfused rat kidney. 6667459 - Carcinogenic activity of farfugium japonicum and senecio cannabifolius. 11063009 - Thermal stability of bone collagen as an indicator of bone turnover in gonadectomized a... 3943099 - Peroxisome proliferation and lipid peroxidation in rat liver. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Arzneimittel-Forschung Volume: 28 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1978 |
Date Detail:
|
Created Date: 1978-07-24 Completed Date: 1978-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 407-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoradiography Fibrin / metabolism Fibrinogen / diagnostic use Hepatectomy Iodine Radioisotopes / diagnostic use Liver Circulation / drug effects* Rats Streptokinase / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Iodine Radioisotopes; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of diltiazem Hydrochloride (CRD-401) on renal hemodynamics of dogs.
Next Document: Acute, subacute and chronic toxicity of oxepinac.