Document Detail

Improvement of pancreatic cancer model by modified treatment with N-nitroso-bis (2-oxopropyl) amine.
MedLine Citation:
PMID:  45725     Owner:  NLM     Status:  MEDLINE    
Comparative studies were conducted in 2 groups of Syrian golden hamsters treated with N-nitroso-bis (2-oxopropyl)amine (BOP) weekly for life (group A) or weekly for 6 weeks (group B), and sacrificed at 2-week intervals. Pancreatic neoplasms developed as early as 8 weeks (group B) and 10 weeks (group A); however, in group B there were fewer, smaller lesions, well-differentiated morphologically. Liver neoplasms occurred only in group A, while gallbladder and kidney tumors were seen in both groups. A lower incidence of pulmonary adenomas was found in group B than in group A, which also had pulmonary carcinomas. The results indicate a further advance in the development of a pancreatic cancer model.
P Pour; J Althoff; F W Krüger; U Mohr
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  2     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1994-06-09     Completed Date:  1994-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
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MeSH Terms
Adenocarcinoma / chemically induced
Body Weight / drug effects
Carcinoma in Situ / chemically induced
Carcinoma, Intraductal, Noninfiltrating / chemically induced
Disease Models, Animal*
Lung Neoplasms / chemically induced
Pancreatic Neoplasms / chemically induced*
Time Factors
Reg. No./Substance:
0/Carcinogens; 0/Nitrosamines; 60599-38-4/nitrosobis(2-oxopropyl)amine

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