Document Detail

Improvement of oxygenation induced by aerosolized prostacyclin in a preterm infant with persistent pulmonary hypertension of the newborn.
MedLine Citation:
PMID:  9470085     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Case report on the effect of inhaled prostacyclin in a preterm infant (28 weeks gestational age) with respiratory distress syndrome complicated by marked hypoxemia due to persistent pulmonary hypertension of the newborn. Treatment with surfactant, hyperventilation, and elevation of systemic blood pressure had failed to improve oxygenation. MEASURES: A solution containing 10 micrograms PGI2/ml was aerosolized by the SPAG-2 aerosol-generator and then introduced into the afferent loop of the ventilatory circuit. RESULTS: Oxygenation improved dramatically and worsened when aerosolization was withdrawn. Intravenous prostacyclin had no additional effect on oxygenation. We observed no side effects on blood pressure and no bleeding complications. Inhalation was stopped after 40 hours and the baby was successfully weaned from the ventilator after 108 hours. CONCLUSION: Inhaled PGI2 had a beneficial effect on the oxygenation of a preterm neonate with persistent pulmonary hypertension of the newborn.
V Soditt; C Aring; P Groneck
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  23     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1275-8     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital of the City of Cologne, Germany.
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MeSH Terms
Administration, Inhalation
Anoxia / etiology
Epoprostenol / administration & dosage,  therapeutic use*
Infant, Newborn
Infant, Premature*
Persistent Fetal Circulation Syndrome / drug therapy*
Respiratory Distress Syndrome, Newborn / complications*
Treatment Outcome
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventilator Weaning
Reg. No./Substance:
0/Vasodilator Agents; 35121-78-9/Epoprostenol

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