Document Detail

Improvement of nutritional measures during preoperative parenteral nutrition in patients selected by the prognostic nutritional index: a randomized controlled trial.
MedLine Citation:
PMID:  3148039     Owner:  NLM     Status:  MEDLINE    
Patients undergoing major gastrointestinal surgery who had a prognostic nutritional index (PNI) score of greater than 30% were randomized to receive a preoperative course of 10 days of intravenous nutrition or to undergo surgery at the next convenient operation list. Two groups of 17 patients were well matched for age, sex, and nutritional status. Although they underwent diverse operations, the extent of these was similar: 12 +/- 3 days of parenteral nutrition resulted in weight gain, 3.2 +/- 2.3 kg p less than 0.01; increased triceps skinfold, 0.6 +/- 1.2 mm p less than 0.05; improved immunological state, p less than 0.02; and improved PNI, 5.5 +/- 10.1% p less than 0.05. The changes in serum albumin and transferrin were not significant. There were only three major complications with one death in the treatment group but this was not significantly different from the control group which had six major complications and three deaths. This study suggests that patients with demonstrable nutritional depletion who require major gastrointestinal surgery will benefit from a preoperative course of parenteral nutrition, but to conclusively prove this a large and probably multicentre study will be required.
R C Smith; R Hartemink
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  12     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1988 Nov-Dec
Date Detail:
Created Date:  1989-04-18     Completed Date:  1989-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
Department of Surgery, Concord Hospital, Sydney, Australia.
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MeSH Terms
Aged, 80 and over
Clinical Trials as Topic
Middle Aged
Nutritional Status*
Parenteral Nutrition*
Preoperative Care*
Random Allocation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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