| Improvement of myoclonic epilepsy in Down syndrome treated with levetiracetam. | |
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MedLine Citation:
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PMID: 20483713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Late Onset Myoclonic Epilepsy in Down Syndrome (LOMEDS) is a recognized entity usually preceded by cognitive deterioration. We report two patients with LOMEDS and cognitive decline, aged 52 and 44 years. Continuous video-EEG recording showed generalised spike and slow wave complexes as an ictal correlate of the myoclonic jerks in both patients. Low dose levetiracetam resulted in rapid, sustained seizure freedom in both patients with no reported adverse events. As for other myoclonic epilepsies, levetiracetam appears to be effective for the treatment of LOMEDS, and may be considered as a first line agent for this disorder. |
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Authors:
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Masoud Sangani; Asim Shahid; Shahram Amina; Mohamad Koubeissi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 12 ISSN: 1294-9361 ISO Abbreviation: Epileptic Disord Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: France |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alzheimer Disease / diagnosis Anticonvulsants / therapeutic use* Disease Progression Dose-Response Relationship, Drug Down Syndrome / diagnosis, drug therapy* Drug Administration Schedule Electroencephalography / drug effects Epilepsies, Myoclonic / diagnosis, drug therapy* Humans Middle Aged Piracetam / analogs & derivatives*, therapeutic use Signal Processing, Computer-Assisted |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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