Document Detail

Improvement of myocardial ischemic dysfunction with dichloroacetic acid: experimental study by repeated ischemia in dogs.
MedLine Citation:
PMID:  8606539     Owner:  NLM     Status:  MEDLINE    
We investigated metabolic factors related to the recovery of myocardial function during ischemia and after reperfusion using dichloroacetic acid (DCA) in canine models with repeated 10-min regional ischemia and reperfusion. Administration of 100 mg/kg DCA, which activates pyruvate dehydrogenase, improved regional wall motion significantly as compared with the nontreated controls (p < 0.05). The mechanism was studied by determining changes in myocardial levels of pH, glucose, lactate, and nonesterified fatty acids (NEFA). Glucose extraction was increased significantly during ischemia and reperfusion by the pretreatment of DCA (p < 0.01). the calculated contribution of glucose to myocardial oxidative metabolism during ischemia and reperfusion was greater than that of NEFA and lactate in case of DCA treatment. The uptake of [99mTc]pyrophosphate (PYP), which reflects myocardial injury, was also significantly suppressed by DCA (p < 0.01). pH was not affected by an infusion of DCA. These findings suggest that the activation of glucose metabolism by DCA, which is impaired and reduced during ischemia and reperfusion, may be responsible for the improved myocardial function after reperfusion.
K Okuda; R Nohara; M Fujita; N Tamaki; J Konishi; S Sasayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  26     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-05-23     Completed Date:  1996-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  990-9     Citation Subset:  IM    
Department of Internal Medicine, Kyoto University Hospital, Japan.
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MeSH Terms
Blood Glucose / analysis
Calcium / metabolism
Coronary Circulation / drug effects
Dichloroacetate / pharmacology*
Fatty Acids, Nonesterified / blood
Glucose / metabolism*
Hydrogen-Ion Concentration
Lactates / metabolism
Lactic Acid
Myocardial Ischemia / metabolism*
Myocardial Stunning / metabolism
Technetium Tc 99m Pyrophosphate / diagnostic use
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Technetium Tc 99m Pyrophosphate; 13425-80-4/Dichloroacetate; 50-21-5/Lactic Acid; 50-99-7/Glucose; 7440-70-2/Calcium

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