Document Detail


Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage.
MedLine Citation:
PMID:  11005159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lymphatic system is very important for macromolecular clearance in various tissues, especially in the gingiva. However, the kinetics of macromolecular clearance via the lymph flow in the gingiva are poorly understood. The aim of this study was to investigate whether thermal or mechanical stimulation affects macromolecular clearance via the lymph flow in the gingiva. Carbon black suspension was injected into the mandibular gingiva of anesthetized hamsters and its drainage into cervical lymph nodes was examined. Clearance of 14C-methylated bovine albumin and tritiated water from the gingiva and their drainage into submandibular lymph nodes and blood was quantified. The effect of topical warming or massage on clearance of 14C-methylated albumin from the gingiva during a 15 min period was examined. In addition, the influence of neurochemical antagonists on the stimulatory effect of topical warming on albumin clearance was investigated. Submandibular lymph nodes were clearly delineated by carbon black 10 min after the injection. More radiolabeled albumin appeared in submandibular lymph nodes than in serum, while more tritiated water appeared in serum. Topical warming (45 degrees C, 2 min) and warming plus massage (with a silicon rubber brush, 20 s) decreased the radiolabeled albumin in the gingiva 15 min after the injection. There was less radiolabeled albumin in the gingiva after gingival warming plus massage than after warming. Previous injection of HOE140 or propranolol into the gingiva diminished the stimulatory effect of topical warming on albumin clearance. It was concluded that topical warming plus massage improves macromolecular clearance via the lymph flow in hamster gingiva.
Authors:
A Shimotoyodome; S Meguro; T Hase; I Tokimitsu; A Fujimura; Y Nozaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of periodontal research     Volume:  35     ISSN:  0022-3484     ISO Abbreviation:  J. Periodont. Res.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2001-01-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0055107     Medline TA:  J Periodontal Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  310-7     Citation Subset:  D; IM    
Affiliation:
Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Albumins / diagnostic use,  metabolism
Animals
Cricetinae
Gingiva / anatomy & histology,  metabolism*
Hot Temperature
Lymph / physiology
Lymphatic System / anatomy & histology,  drug effects,  physiology*
Male
Massage
Mesocricetus
Metabolic Clearance Rate
Neurotransmitter Agents / pharmacology
Physical Stimulation
Protein Transport* / drug effects
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Albumins; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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