Document Detail

Improvement of left ventricular mass with antihypertensive therapy in children with hypertension.
MedLine Citation:
PMID:  20393750     Owner:  NLM     Status:  MEDLINE    
There is paucity of data on the regression of left ventricular hypertrophy (LVH) in hypertensive children. This study assessed the effects of antihypertensive therapy on left ventricular mass in children with and without LVH. Medical records of hypertensive patients who had a baseline and follow-up echocardiogram (echo 1, echo 2) were reviewed. Fifteen of 22 treated patients had LVH at echo 1. Enalapril alone or combined was used in 21/22 cases. Echo 2 was performed at a mean interval of 15 +/- 7 months. The LVH group showed significant decrease in systolic blood pressure z-score (SBPZ) (2.89 +/-1.61 to 1.40 +/- 1.19; p=0.01), diastolic blood pressure z-score (DBPZ) (1.44 +/- 0.90 to 0.26 +/- 0.82; p<0.001), and LV mass index (LVMI) (56.2 +/- 12.50 to 43.7 +/- 8.30; p=0.001), but no significant change in body mass index z-score (BMIZ) (1.79 +/- 0.75 to 1.69 +/- 0.69; p=0.74). In the no-LVH group, SBPZ (3.03 +/- 1.68 to 2.27 +/- 1.81; p=0.356), DBPZ (1.00 +/- 0.87 to 0.63 +/- 0.68; p=0.409), BMIZ (1.08 +/- 0.98 to 1.27 +/- 0.89; p=0.672), and LVMI (29.47 +/- 5.51 to 33.89 +/ -3.06;p=0.374) did not change significantly. Simple linear regression demonstrated that the change in LVMI in the combined group had a significant correlation (r=0.477; p=0.025) with the percentage change in SBPZ. This study demonstrates that LVH in hypertensive children improves with effective blood pressure control.
Juan C Kupferman; Kara Paterno; Joseph Mahgerefteh; Murali Pagala; Meg Golden; Irene D Lytrivi; Prema Ramaswamy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  25     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1513-8     Citation Subset:  IM    
Division of Pediatric Nephrology and Hypertension, Maimonides Medical Center, Brooklyn, NY 11219, USA.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Body Mass Index
Heart Ventricles / physiopathology,  ultrasonography
Hypertension / drug therapy*,  physiopathology*,  ultrasonography
Hypertrophy, Left Ventricular / drug therapy,  physiopathology,  ultrasonography
Reg. No./Substance:
0/Antihypertensive Agents

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