| Improvement of left ventricular diastolic function induced by β-blockade A comparison between nebivolol and metoprolol. | |
| | |
MedLine Citation:
|
PMID: 21640121 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Enhanced adrenergic drive is involved in the development of left ventricular (LV) diastolic dysfunction observed in metabolic syndrome (MS). Thus, β-blockers might improve LV dysfunction observed in MS, but whether this occurs is unknown. METHODS: We assessed in Zucker fa/fa rats the effects of short- (5days) and long-term (90days) metoprolol ('pure' β-blockade; 80mg/kg/day) or nebivolol (β-blocker with vasodilating properties; 5mg/kg/day) treatment on LV hemodynamics and remodeling, as well as the long-term effects on coronary and peripheral endothelial dysfunction. RESULTS: At identical degree of β(1)-receptor blockade, metoprolol and nebivolol decreased heart rate to the same extent and preserved cardiac output via increased stroke volume. None of the β-blockers, either after long- or short-term administration, modified LV end-systolic pressure-volume relation. Both β-blockers reduced, after long-term administration, LV end-diastolic pressure, Tau and end-diastolic pressure-volume relation, and this was associated with reduced LV collagen density, but not heart weight. Similar hemodynamic effects were also observed after short-term nebivolol, but not short-term metoprolol. These short-term effects of nebivolol were abolished by NO synthase inhibition. At the vascular level, nebivolol, and to a lesser extend metoprolol, improved NO dependent coronary vasorelaxation, which was abolished by NO synthase inhibition. CONCLUSIONS: In a model of MS, the β-blockers metoprolol and nebivolol improve to the same extent LV hemodynamics, remodeling and diastolic function, but nebivolol prevent more markedly endothelium dependent vasorelaxation involving a more marked enhancement of NO bio-availability. |
| | |
Authors:
|
Yuehua Fang; Lionel Nicol; Najah Harouki; Christelle Monteil; Didier Wecker; Manuelle Debunne; Fabrice Bauer; Françoise Lallemand; Vincent Richard; Christian Thuillez; Paul Mulder |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-24 |
Journal Detail:
|
Title: Journal of molecular and cellular cardiology Volume: - ISSN: 1095-8584 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
INSERM U644, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides n°23 Institut de Recherche et d'Innovation Biomédicale de Haute Normandie, UFR de Médecine et de Pharmacie, Rouen, France; Cardiology Department, Shanghai RuiJin Hospital, Jiao Tong University, Shanghai China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic and electron-microscopic characterization of Rickettsiella bacteria from the manuka beetle, ...
Next Document: EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that i...