Document Detail

Improvement of intra-epidermal nerve fiber density in hypothyroidism after L-thyroxine therapy.
MedLine Citation:
PMID:  22630564     Owner:  NLM     Status:  Publisher    
Hypothyroidism may induce a wide range of neurological complaints, frequently described in the past, but nowadays rarely reported due to earlier diagnosis and treatment. By investigating a series of neurologically asymptomatic, untreated patients with hypothyroidism, either overt (OH) or subclinical (SH), we found in 11% of them an asymptomatic polyneuropathy, as assessed by conventional neurophysiological studies (1) . In the same group of patients, using a skin biopsy technique, we observed a significant reduction of intra-epidermal nerve fiber (IENF) density with a prevalence of 60% and 25% in OH and SH, respectively © 2012 Blackwell Publishing Ltd.
Flavia Magri; Michelangelo Buonocore; Antonella Camera; Valentina Capelli; Antonio Oliviero; Mario Rotondi; Anna Gatti; Luca Chiovato
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Publication Detail:
Type:  LETTER     Date:  2012-5-27
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., University of Pavia, Pavia, Italy.
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