| Improvement of interferon-beta related skin reactions after diluent halving: first experience of five patients. | |
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MedLine Citation:
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PMID: 22927749 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The spectrum of side effects related to interferon beta-1b (INF-1b) treatment may compromise long-term adherence. METHODS: Five INF-1b-treated multiple sclerosis patients with poor skin tolerability and clinical stability were instructed to dissolve the established (250 μg) INF-1b dose in half (0.5 mL) the standard diluent (1.0 mL, 0.54% sodium chloride solution), and were followed for 9 months. RESULTS: Halving the volume of the treatment diluent was associated with significant improvement of skin side effects profile in all patients. The improvement was sustained for 9 months. CONCLUSION: Halving the volume of the INF-1b diluent could represent a different strategy to optimize skin tolerability and adherence in some multiple sclerosis patients. |
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Authors:
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Chiara Zecca; Nikhil Yawalkar; Claudio Gobbi |
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Publication Detail:
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Type: Journal Article Date: 2012-08-08 |
Journal Detail:
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Title: Patient preference and adherence Volume: 6 ISSN: 1177-889X ISO Abbreviation: Patient Prefer Adherence Publication Date: 2012 |
Date Detail:
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Created Date: 2012-08-28 Completed Date: 2012-10-02 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 101475748 Medline TA: Patient Prefer Adherence Country: New Zealand |
Other Details:
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Languages: eng Pagination: 565-7 Citation Subset: - |
Affiliation:
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Neurocenter of Southern Switzerland, Lugano. |
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