Document Detail


Improvement of interferon-beta related skin reactions after diluent halving: first experience of five patients.
MedLine Citation:
PMID:  22927749     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The spectrum of side effects related to interferon beta-1b (INF-1b) treatment may compromise long-term adherence.
METHODS: Five INF-1b-treated multiple sclerosis patients with poor skin tolerability and clinical stability were instructed to dissolve the established (250 μg) INF-1b dose in half (0.5 mL) the standard diluent (1.0 mL, 0.54% sodium chloride solution), and were followed for 9 months.
RESULTS: Halving the volume of the treatment diluent was associated with significant improvement of skin side effects profile in all patients. The improvement was sustained for 9 months.
CONCLUSION: Halving the volume of the INF-1b diluent could represent a different strategy to optimize skin tolerability and adherence in some multiple sclerosis patients.
Authors:
Chiara Zecca; Nikhil Yawalkar; Claudio Gobbi
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Publication Detail:
Type:  Journal Article     Date:  2012-08-08
Journal Detail:
Title:  Patient preference and adherence     Volume:  6     ISSN:  1177-889X     ISO Abbreviation:  Patient Prefer Adherence     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101475748     Medline TA:  Patient Prefer Adherence     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  565-7     Citation Subset:  -    
Affiliation:
Neurocenter of Southern Switzerland, Lugano.
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