Document Detail


Improvement in severe onchocercal skin disease after a single dose of ivermectin.
MedLine Citation:
PMID:  2029016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Skin disease is the most common clinically important manifestation of onchocerciasis. Ivermectin, a newly available drug, is well tolerated and effective in Onchocerca volvulus infection. However, little information is available regarding its effect on onchocercal skin disease. The purpose of this study was to examine, in patients with well-characterized onchodermatitis, the effect of a single dose of ivermectin. SUBJECTS AND METHODS: Twenty-one persons with severe onchodermatitis were followed over a 6-month period. In order to evaluate the effect of ivermectin on their skin lesions, photographic transparencies were made before treatment and at 3 and 6 months after treatment. These were then evaluated in a blinded fashion. RESULTS: Following a single dose of 150 micrograms/kg, there was a significant improvement in dermatitis in the first 3 months after treatment. All 14 persons with the worst skin disease showed improvement. The drug had no demonstrable effect on depigmented lesions over the period of observation. Treatment was well tolerated. CONCLUSION: Single-dose ivermectin shows promise as the first acceptable treatment for severe onchocercal dermatitis.
Authors:
M Pacqué; C Elmets; Z D Dukuly; B Muñoz; A T White; H R Taylor; B M Greene
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  90     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  590-4     Citation Subset:  AIM; IM    
Affiliation:
Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antiparasitic Agents*
Female
Follow-Up Studies
Humans
Ivermectin / administration & dosage,  pharmacology,  therapeutic use*
Liberia / epidemiology
Male
Middle Aged
Onchocerciasis / drug therapy*,  epidemiology,  pathology
Skin Diseases, Parasitic / epidemiology,  pathology
Grant Support
ID/Acronym/Agency:
AI 15351/AI/NIAID NIH HHS; EY 03318/EY/NEI NIH HHS; RR 04060/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antiparasitic Agents; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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