| Improvement in severe onchocercal skin disease after a single dose of ivermectin. | |
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MedLine Citation:
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PMID: 2029016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Skin disease is the most common clinically important manifestation of onchocerciasis. Ivermectin, a newly available drug, is well tolerated and effective in Onchocerca volvulus infection. However, little information is available regarding its effect on onchocercal skin disease. The purpose of this study was to examine, in patients with well-characterized onchodermatitis, the effect of a single dose of ivermectin. SUBJECTS AND METHODS: Twenty-one persons with severe onchodermatitis were followed over a 6-month period. In order to evaluate the effect of ivermectin on their skin lesions, photographic transparencies were made before treatment and at 3 and 6 months after treatment. These were then evaluated in a blinded fashion. RESULTS: Following a single dose of 150 micrograms/kg, there was a significant improvement in dermatitis in the first 3 months after treatment. All 14 persons with the worst skin disease showed improvement. The drug had no demonstrable effect on depigmented lesions over the period of observation. Treatment was well tolerated. CONCLUSION: Single-dose ivermectin shows promise as the first acceptable treatment for severe onchocercal dermatitis. |
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Authors:
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M Pacqué; C Elmets; Z D Dukuly; B Muñoz; A T White; H R Taylor; B M Greene |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 90 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-06-13 Completed Date: 1991-06-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 590-4 Citation Subset: AIM; IM |
Affiliation:
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Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antiparasitic Agents* Female Follow-Up Studies Humans Ivermectin / administration & dosage, pharmacology, therapeutic use* Liberia / epidemiology Male Middle Aged Onchocerciasis / drug therapy*, epidemiology, pathology Skin Diseases, Parasitic / epidemiology, pathology |
| Grant Support | |
ID/Acronym/Agency:
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AI 15351/AI/NIAID NIH HHS; EY 03318/EY/NEI NIH HHS; RR 04060/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiparasitic Agents; 70288-86-7/Ivermectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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