Document Detail

Improvement in regional ventilation and perfusion after radiotherapy for unresectable carcinoma of the bronchus.
MedLine Citation:
PMID:  222126     Owner:  NLM     Status:  MEDLINE    
Ventilation/perfusion scans were obtained in 45 patients with unresectable carcinoma of the bronchus. Of these 45 patients, 35 were reinvestigated shortly after radiotherapy and 17 of them had additional later follow-up studies. Both ventilation and perfusion were always abnormal in the lung affected by the tumor; perfusion was usually more impaired than ventilation. These abnormalities were difficult to detect or to evaluate from the standard chest radiograph. After radiotherapy, ventilation improved in 83% and perfusion in 86% of the patients. This improvement was associated with amelioration of breathlessness, which improved in 74% of the patients. Slow but progressive deterioration of regional ventilation and perfusion were subsequently observed. This was often associated with the development of radiation fibrosis. Spirometric measurements (VC, FEV1) were moderately imparied at the initial assessment (83% and 66% of predicted, respectively), probably due to coexisting chronic airway obstruction, and did not show significant changes after radiotherapy or during the follow-up. Radionuclide studies of regional perfusion and ventilation proved more sensitive and more specific than tests of overall lung function for the functional assessment and follow-up of patients with unresectable carcinoma of the bronchus.
F Fazio; T A Pratt; C G McKenzie; R E Steiner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  133     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-200     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / radionuclide imaging,  radiotherapy
Bronchial Neoplasms / radiography,  radionuclide imaging,  radiotherapy*
Carcinoma, Small Cell / radionuclide imaging,  radiotherapy
Carcinoma, Squamous Cell / radionuclide imaging,  radiotherapy
Follow-Up Studies
Lung / physiopathology
Lung Volume Measurements
Middle Aged
Pulmonary Circulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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