Document Detail

Improvement in the preservation of ischemically impaired renal transplants of pigs by iloprost (ZK 36 374).
MedLine Citation:
PMID:  2419922     Owner:  NLM     Status:  MEDLINE    
Kidneys of five pigs were preoperatively perfused with iloprost in situ (infusion of 0.5 microgram X kg-1 for 15 minutes) and exposed to a warm ischemic period of 45 minutes. The behaviour of these kidneys during initial perfusion by gravity and hypothermic mechanical perfusion for 24 hours was comparable to that of kidneys having had a warm ischemic period of less than 5 minutes. After retransplantation all kidneys showed a sufficient blood flow and immediate production of urine during the test period of 3 hours.
B Langkopf; U Rebmann; J Schabel; H D Pauer; H Heynemann; W Förster
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  21     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular Agents / pharmacology*
Epoprostenol / pharmacology*
Ischemia / physiopathology*
Kidney / blood supply,  drug effects
Kidney Transplantation*
Renal Artery / drug effects,  physiology
Renal Circulation / drug effects*
Tissue Preservation
Vascular Resistance / drug effects
Reg. No./Substance:
0/Cardiovascular Agents; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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