Document Detail

Improvement in lung diffusion by endothelin A receptor blockade at high altitude.
MedLine Citation:
PMID:  21979801     Owner:  NLM     Status:  MEDLINE    
Lung diffusing capacity has been reported variably in high-altitude newcomers and may be in relation to different pulmonary vascular resistance (PVR). Twenty-two healthy volunteers were investigated at sea level and at 5,050 m before and after random double-blind intake of the endothelin A receptor blocker sitaxsentan (100 mg/day) vs. a placebo during 1 wk. PVR was estimated by Doppler echocardiography, and exercise capacity by maximal oxygen uptake (Vo(2 max)). The diffusing capacities for nitric oxide (DL(NO)) and carbon monoxide (DL(CO)) were measured using a single-breath method before and 30 min after maximal exercise. The membrane component of DL(CO) (Dm) and capillary volume (Vc) was calculated with corrections for hemoglobin, alveolar volume, and barometric pressure. Altitude exposure was associated with unchanged DL(CO), DL(NO), and Dm but a slight decrease in Vc. Exercise at altitude decreased DL(NO) and Dm. Sitaxsentan intake improved Vo(2 max) together with an increase in resting and postexercise DL(NO) and Dm. Sitaxsentan-induced decrease in PVR was inversely correlated to DL(NO). Both DL(CO) and DL(NO) were correlated to Vo(2 max) at sea level (r = 0.41-0.42, P < 0.1) and more so at altitude (r = 0.56-0.59, P < 0.05). Pharmacological pulmonary vasodilation improves the membrane component of lung diffusion in high-altitude newcomers, which may contribute to exercise capacity.
Claire de Bisschop; Jean-Benoit Martinot; Gil Leurquin-Sterk; Vitalie Faoro; Hervé Guénard; Robert Naeije
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-10-06
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-23     Completed Date:  2012-08-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
Laboratory of Physiologic Adaptations to Physical Activities, UPRES EA 3813, Poitiers University, Poitiers, France.
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MeSH Terms
Double-Blind Method
Exercise Tolerance / drug effects,  physiology
Isoxazoles / pharmacology*
Middle Aged
Prospective Studies
Pulmonary Diffusing Capacity / drug effects,  physiology*
Receptor, Endothelin A / antagonists & inhibitors*,  physiology*
Thiophenes / pharmacology*
Young Adult
Reg. No./Substance:
0/Isoxazoles; 0/Receptor, Endothelin A; 0/Thiophenes; 0/sitaxsentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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