| Improvement in long-term prognosis of elderly patients with acute myocardial infarction after the introduction of intravenous thrombolytic therapy. | |
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MedLine Citation:
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PMID: 9862099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Survival rate from a "thrombolytic" period of 351 patients above 66 years of age with acute myocardial infarction (AMI) was compared with that of 289 patients from a "prethrombolytic" period. The two groups were comparable regarding sex, age, previous AMI, cerebrovascular events, morbidity and mortality during admission. Survival rates after four years were 45.0% in the "thrombolytic" group and 38.4% in the "prethrombolytic" group (p = 0.047, log rank test). Using the Cox proportional hazard analysis, thrombolytic therapy was shown to be an independent prognostic predictor in "the thrombolytic population" with a relative risk of death from day 30 to end of follow-up of 0.4 (95% confidence interval 0.2-0.8). No interaction was found between age and thrombolysis. Although only one-fifth of the patients with AMI were eligible for thrombolysis, this treatment may have contributed to the improved long-term survival. |
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Authors:
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J K Madsen; F Pedersen; H Nielsen; G V Jensen; J F Hansen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 32 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-02-25 Completed Date: 1999-02-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: NORWAY |
Other Details:
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Languages: eng Pagination: 365-70 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hvidovre Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Female Fibrinolytic Agents / administration & dosage, therapeutic use Follow-Up Studies Humans Male Myocardial Infarction / drug therapy*, mortality* Prognosis Proportional Hazards Models Streptokinase / administration & dosage, therapeutic use Survival Rate Thrombolytic Therapy* Time Factors Tissue Plasminogen Activator / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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