| Improvement in lipid profiles in antiretroviral-experienced HIV-positive patients with hyperlipidemia after a switch to unboosted atazanavir. | |
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MedLine Citation:
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PMID: 19346966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The primary objective was to compare the change in fasting low-density lipoprotein (LDL) cholesterol from baseline to week 12 between patients receiving an atazanavir-containing regimen and those receiving comparator protease inhibitor (PI) regimens. DESIGN: AI424-067 was a 48-week, open-label, randomized, prospective study of 246 patients on PI-based regimens with hyperlipidemia [fasting LDL cholesterol >130 mg/dL (>3.4 mmol/L)] and with HIV RNA <50 copies per milliliter. Patients were randomized to switch to atazanavir (400 mg once daily) on day 1 (immediate switch) or maintain current PI regimen for the first 24 weeks, then switch to atazanavir (delayed switch). METHODS: Plasma lipid levels were compared with baseline values at weeks 12, 24, and 48. Safety, viral load, and CD4 profiles were also evaluated. RESULTS: At week 12, the mean percent changes in LDL cholesterol from baseline for the immediate-switch and delayed-switch groups were -15% and +1%, respectively (P < 0.0001). Favorable LDL cholesterol levels in the immediate-switch group were sustained through week 48. Both groups maintained comparable virologic control. Switching to atazanavir did not produce a significant change in safety or tolerability. CONCLUSIONS: A switch-either immediate or delayed-from a boosted or unboosted PI to unboosted atazanavir in patients with hyperlipidemia was associated with improvements in plasma lipid parameters without loss of virological suppression. |
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Authors:
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Michael Sension; Jose Luiz de Andrade Neto; Beatriz Grinsztejn; Jean Michel Molina; Isidro Zavala; Juan González-García; Alice Donnelly; Phillip Phiri; Emilio Ledesma; Donnie McGrath; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 51 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-06-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 153-62 Citation Subset: IM; X |
Affiliation:
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HIV Clinical Research, North Broward Hospital District, Ft Lauderdale, FL 33311, USA. msension@nbhd.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-HIV Agents / administration & dosage, adverse effects, therapeutic use* Cholesterol, LDL / blood* Drug Administration Schedule Drug Therapy, Combination Female HIV Infections / complications*, drug therapy* Humans Hyperlipidemias / blood, complications* Male Middle Aged Oligopeptides / therapeutic use* Pyridines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Cholesterol, LDL; 0/Oligopeptides; 0/Pyridines; 198904-31-3/atazanavir |
| Investigator | |
Investigator/Affiliation:
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William Powderly / ; Joseph Jemsek / ; Robert Eng / ; Dorece Norris / ; Daniel Seekins / ; Margaret Fischl / ; Chris Tsoukas / ; Livette Johnson / ; Sharon Walmsley / ; Juan Sierra / ; Stefan Esser / ; Reinhold Schmidth / ; Fernando Aiuti / ; Alain Lafeuillade / ; Jacques Reynes / ; Daniel Vittecoq / ; Michele Bentata / ; Frederic Lucht / ; Miguel Jimenez Gorgolas / ; Juan Gonzalez Garcia / ; Juan Maria Gonzalez Lahoz / ; Pere Domingo / ; Giuliano Stagni / ; Karam Mounzer / ; Margaret Johnson / ; Gary L Simon / ; Gracy McComsey / ; Mark Bloch / ; Cheryl K MacDonald / ; Javier O Morales Ramirez / ; Rohut Talwani / ; Leonard Slater / ; Isidro G Zavala Trujillo / ; Jean-Michel Molina / ; Cecilia Shikuma / ; Francisco Antunes / ; Beatriz Grinsztejn / ; Jose Henrique Piloto / ; Flavio Telles / ; Jose Luiz Andrade / ; Waldo Belloso / ; Carlos Zala / ; Claudia Rodriguez / ; Sergio Lupo / ; Elida Pallone / ; Angel Minguez / ; Arnaldo Casiro / ; Norma Luna / ; Jorge Corral / ; Abel Jasovich / ; Isabel Cassetti / ; Luis Noriega / ; Carlos Perez / ; Marcelo Wolff / ; Juan Echevarria / ; Raul Salazar / ; Andres Paredes / ; Frederico Rangel / |
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