Document Detail

Improvement in left ventricular diastolic function during intravenous and oral diltiazem therapy in patients with hypertrophic cardiomyopathy: an echocardiographic study.
MedLine Citation:
PMID:  6541866     Owner:  NLM     Status:  MEDLINE    
M-mode echocardiography was used to evaluate the acute effect of intravenously administered diltiazem, 10 mg, and the chronic effects of oral diltiazem, 180 mg/day, and propranolol, 60 to 120 mg/day, administered for 2 weeks on left ventricular (LV) systolic and diastolic function in 13 patients with hypertrophic cardiomyopathy. Intravenous injection of diltiazem reduced isovolumic relaxation time from 114 +/- 26 to 99 +/- 21 ms (p less than 0.01) and the time to peak rate of LV dimensional lengthening from 166 +/- 17 to 133 +/- 10 ms (p less than 0.01), without significant changes of LV dimensions or fractional shortening. No significant changes were observed in LV dimensions or fractional shortening, but a significant increase in peak rate of LV dimensional lengthening (from 4.1 +/- 1.5 to 4.8 +/- 1.6/s, p less than 0.05) and a reduction in isovolumic relaxation time (from 105 +/- 26 to 77 +/- 23 ms, p less than 0.01) and the time to peak rate of LV dimensional lengthening (from 156 +/- 23 to 124 +/- 20 ms, p less than 0.01) occurred during the oral administration of diltiazem. In contrast, propranolol caused no significant changes in these values. Thus, diltiazem improves LV relaxation and diastolic filling without altering LV systolic function in patients with hypertrophic cardiomyopathy.
M Suwa; Y Hirota; K Kawamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  54     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1047-53     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Benzazepines / therapeutic use*
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology
Diltiazem / administration & dosage,  therapeutic use*
Heart / physiopathology*
Injections, Intravenous
Middle Aged
Propranolol / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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