| Improvement in intestinal coenzyme q10 absorption by food intake. | |
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MedLine Citation:
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PMID: 17666877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coenzyme Q10 (CoQ10) is widely consumed as a food supplement because of its recognition as an important nutrient in supporting human health. Absorption of compounds from the gastrointestinal tract is one of the important determinants of oral bioavailability. However, the absorption of dietary CoQ10 is slow and limited due to its hydrophobicity and large molecular weight. The absorption of orally applied compounds can be enhanced by interactions with food or food components. Thus, we investigated the effect of food intake on the absorption of CoQ10 after oral supplementation. In this study, we demonstrated that food intake enhanced the intestinal absorption of CoQ10. In order to improve intestinal absorption of CoQ10 after oral supplementation, we developed an emulsion formulation. Intestinal absorption of CoQ10 after administration of the emulsion formulation was also enhanced by food intake. Moreover, the peak concentration and the extent of absorption after administration of the emulsion formulation were greater than those after administration of a suspension formulation. It is possible that administration of CoQ10 in an emulsion formulation enhances the pharmacological effects of CoQ10. |
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Authors:
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Akiko Ochiai; Shirou Itagaki; Toshimitsu Kurokawa; Masaki Kobayashi; Takeshi Hirano; Ken Iseki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 127 ISSN: 0031-6903 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 1251-4 Citation Subset: IM |
Affiliation:
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Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Biological Availability Coenzymes / administration & dosage, pharmacokinetics Eating / physiology* Emulsions Intestinal Absorption* Male Molecular Weight Rats Rats, Wistar Ubiquinone / administration & dosage, analogs & derivatives*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Coenzymes; 0/Emulsions; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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