Document Detail

Improvement in intestinal coenzyme q10 absorption by food intake.
MedLine Citation:
PMID:  17666877     Owner:  NLM     Status:  MEDLINE    
Coenzyme Q10 (CoQ10) is widely consumed as a food supplement because of its recognition as an important nutrient in supporting human health. Absorption of compounds from the gastrointestinal tract is one of the important determinants of oral bioavailability. However, the absorption of dietary CoQ10 is slow and limited due to its hydrophobicity and large molecular weight. The absorption of orally applied compounds can be enhanced by interactions with food or food components. Thus, we investigated the effect of food intake on the absorption of CoQ10 after oral supplementation. In this study, we demonstrated that food intake enhanced the intestinal absorption of CoQ10. In order to improve intestinal absorption of CoQ10 after oral supplementation, we developed an emulsion formulation. Intestinal absorption of CoQ10 after administration of the emulsion formulation was also enhanced by food intake. Moreover, the peak concentration and the extent of absorption after administration of the emulsion formulation were greater than those after administration of a suspension formulation. It is possible that administration of CoQ10 in an emulsion formulation enhances the pharmacological effects of CoQ10.
Akiko Ochiai; Shirou Itagaki; Toshimitsu Kurokawa; Masaki Kobayashi; Takeshi Hirano; Ken Iseki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  127     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1251-4     Citation Subset:  IM    
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Administration, Oral
Biological Availability
Coenzymes / administration & dosage,  pharmacokinetics
Eating / physiology*
Intestinal Absorption*
Molecular Weight
Rats, Wistar
Ubiquinone / administration & dosage,  analogs & derivatives*,  pharmacokinetics
Reg. No./Substance:
0/Coenzymes; 0/Emulsions; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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