| Improvement in hepatopulmonary syndrome after methadone withdrawal: a case report with implications for disease mechanism. | |
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MedLine Citation:
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PMID: 20583080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous resolution of hepatopulmonary syndrome (HPS) without liver transplantation or improvement in the underlying liver disease has rarely been reported in the literature. Increased endogenous production of nitric oxide has been implicated in the pathogenesis of HPS. We report the case of a 50-year-old man with hepatitis C cirrhosis who demonstrated dramatic improvement in HPS after withdrawal from chronic methadone therapy. We speculate on the potential role of opiate receptors in the pulmonary vasculature and their effect on nitric oxide signaling as a potential mechanism accounting for the patient's clinical improvement. |
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Authors:
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Edmund M T Lau; Geoffrey McCaughan; Paul J Torzillo |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 16 ISSN: 1527-6473 ISO Abbreviation: Liver Transpl. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
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Languages: eng Pagination: 870-3 Citation Subset: IM |
Affiliation:
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Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. emtlau@bigpond.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Hepatitis C
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complications Hepatopulmonary Syndrome / etiology, metabolism, rehabilitation* Humans Liver Cirrhosis / complications, virology Male Methadone / therapeutic use* Middle Aged Narcotics / therapeutic use* Nitric Oxide / metabolism Receptors, Opioid / metabolism Signal Transduction / physiology Withholding Treatment* |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 0/Receptors, Opioid; 10102-43-9/Nitric Oxide; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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