Document Detail

Improvement in corneal scarring following bacterial keratitis.
MedLine Citation:
PMID:  23238443     Owner:  NLM     Status:  MEDLINE    
AIM: Bacterial keratitis results in corneal scarring and subsequent visual impairment. The long-term evolution of corneal scars has not been well described. In this case series, we identified patients who had improvement in corneal scarring and visual acuity from a clinical trial for bacterial keratitis.
METHODS: We searched the records of the Steroids for Corneal Ulcers Trial (SCUT) for patients who had improvement in vision between the 3-month and 12-month visits and reviewed their clinical photographs.
RESULTS: Of the 500 patients enrolled in SCUT, five patients with large central corneal scars due to bacterial keratitis are presented. All experienced improvement in rigid contact lens-corrected visual acuity from months 3 to 12. All patients also had marked improvement in corneal opacity during the same time period. None of the patients opted to have penetrating keratoplasty.
CONCLUSIONS: Corneal scars may continue to improve even many months after a bacterial corneal ulcer has healed. The corneal remodeling can be accompanied by considerable improvement in visual acuity, such that corneal transplantation may not be necessary.
S M McClintic; M Srinivasan; J Mascarenhas; D A Greninger; N R Acharya; T M Lietman; J D Keenan
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-14
Journal Detail:
Title:  Eye (London, England)     Volume:  27     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-14     Completed Date:  2013-08-02     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
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MeSH Terms
Aza Compounds / therapeutic use
Cicatrix / physiopathology*
Corneal Ulcer / drug therapy,  microbiology,  physiopathology*
Eye Infections, Bacterial / drug therapy,  microbiology,  physiopathology*
Middle Aged
Ophthalmic Solutions
Pneumococcal Infections / drug therapy,  microbiology,  physiopathology*
Prednisolone / analogs & derivatives,  therapeutic use
Pseudomonas Infections / drug therapy,  microbiology,  physiopathology*
Quinolines / therapeutic use
Vision Disorders / physiopathology*
Visual Acuity / physiology
Grant Support
K23 EY019071/EY/NEI NIH HHS; K23 EY017897/EY/NEI NIH HHS; U10 EY015114/EY/NEI NIH HHS
Reg. No./Substance:
0/Aza Compounds; 0/Ophthalmic Solutions; 0/Quinolines; 752SY38R6C/prednisolone phosphate; 9PHQ9Y1OLM/Prednisolone; U188XYD42P/moxifloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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