| Improvement in circulatory and oxygenation status by perflubron emulsion (Oxygent HT) in a canine model of surgical hemodilution. | |
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MedLine Citation:
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PMID: 7849968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the effect of a low dose of Oxygent HT on hemodynamics and oxygen transport variables in a canine model of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg Oxygent HT (90% w/v perflubron emulsion [perfluorooctyl bromide], Alliance Pharmaceutical Corp.) and both groups (7 controls and 10 treated) were further hemodiluted using 6% hydroxyethyl starch until cardiorespiratory decompensation occurred. Pulmonary artery catheterization data and oxygen transport variables were recorded at Hb decrements of 1 g/dL breathing room air. There was no difference among groups during initial hemodilution. However, in the Oxygent HT group there was a statistically significant improvement in mean arterial pressure, CVP, cardiac output, PvO2, SvO2, DO2, and pulmonary venous admixture shunt during profound hemodilution to Hb levels of 6, 5, and 4 g/dL. A low dose of Oxygent HT offered benefit in improving hemodynamics and oxygen transport parameters even under air breathing conditions in a model of surgical hemodilution. This effect was most apparent at lower levels of Hb. |
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Authors:
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A C Cernaianu; R K Spence; T V Vassilidze; J G Gallueci; T Gaprindashvili; A Olah; R L Weiss; J H Cilley; P E Keipert; N S Faithfull |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 22 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 965-77 Citation Subset: IM |
Affiliation:
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Department of Surgery and Medicine, UMDNJ-Robert Wood Johnson Medical School, Camden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Blood Substitutes / pharmacology* Disease Models, Animal Dogs Emulsions Fluorocarbons / pharmacology* Hemodilution* Hemodynamics / drug effects* Oxygen / blood* |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons; 423-55-2/perflubron; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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