Document Detail

Improvement in circulatory and oxygenation status by perflubron emulsion (Oxygent HT) in a canine model of surgical hemodilution.
MedLine Citation:
PMID:  7849968     Owner:  NLM     Status:  MEDLINE    
To examine the effect of a low dose of Oxygent HT on hemodynamics and oxygen transport variables in a canine model of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg Oxygent HT (90% w/v perflubron emulsion [perfluorooctyl bromide], Alliance Pharmaceutical Corp.) and both groups (7 controls and 10 treated) were further hemodiluted using 6% hydroxyethyl starch until cardiorespiratory decompensation occurred. Pulmonary artery catheterization data and oxygen transport variables were recorded at Hb decrements of 1 g/dL breathing room air. There was no difference among groups during initial hemodilution. However, in the Oxygent HT group there was a statistically significant improvement in mean arterial pressure, CVP, cardiac output, PvO2, SvO2, DO2, and pulmonary venous admixture shunt during profound hemodilution to Hb levels of 6, 5, and 4 g/dL. A low dose of Oxygent HT offered benefit in improving hemodynamics and oxygen transport parameters even under air breathing conditions in a model of surgical hemodilution. This effect was most apparent at lower levels of Hb.
A C Cernaianu; R K Spence; T V Vassilidze; J G Gallueci; T Gaprindashvili; A Olah; R L Weiss; J H Cilley; P E Keipert; N S Faithfull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  22     ISSN:  1073-1199     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  965-77     Citation Subset:  IM    
Department of Surgery and Medicine, UMDNJ-Robert Wood Johnson Medical School, Camden.
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MeSH Terms
Biological Transport / drug effects
Blood Substitutes / pharmacology*
Disease Models, Animal
Fluorocarbons / pharmacology*
Hemodynamics / drug effects*
Oxygen / blood*
Reg. No./Substance:
0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons; 423-55-2/perflubron; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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