| Improvement in the capillarity of the left ventricular wall of stroke-prone spontaneously hypertensive rats following angiotensin II receptor blockade. | |
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MedLine Citation:
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PMID: 10369385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the angiotensin II type 1 receptor blockade, candesartan cilexetil (TCV116), on the capillarity of the innermost region of the left ventricular subendocardium were studied in stroke-prone spontaneously hypertensive rats (SHRSP). The rats were fed for 32 days on chow that contained TCV116, the average dose being 0.96 mg/kg/day. Compared with values from control SHRSP, the systolic blood pressure, left ventricular weight and cross-sectional area of cardiomyocytes decreased. A significant increase in the total capillary density was coupled with a decrease of capillary domain areas in all capillary portions. The proportion of venular capillary portions, which was low in control SHRSP, increased significantly, suggesting neoangiogenesis of capillaries. The results indicate that AT1-receptor blockade caused regression of the hypertrophied cardiomyocytes and improved capillarity of the left ventricular wall. |
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Authors:
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Z Xie; M Gao; H Togashi; H Saito; T Koyama |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 21 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-26 Completed Date: 1999-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 441-52 Citation Subset: IM |
Affiliation:
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Research Institute for Electronic Science, Sapporo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / therapeutic use* Benzimidazoles / therapeutic use* Biphenyl Compounds / therapeutic use* Capillaries / drug effects Coronary Circulation / drug effects* Coronary Vessels / drug effects, pathology Follow-Up Studies Heart Ventricles / drug effects, metabolism, pathology* Hypertension / drug therapy*, metabolism, pathology Hypertrophy, Left Ventricular / drug therapy, metabolism, pathology Male Rats Rats, Inbred SHR Receptors, Angiotensin / antagonists & inhibitors* Tetrazoles* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Receptors, Angiotensin; 0/Tetrazoles; 145040-37-5/candesartan cilexetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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