| Improvement of gas transfer by hemosome. | |
| | |
MedLine Citation:
|
PMID: 20383855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intravascular oxidation is a respiratory assist method used to treat acute respiratory distress syndrome (ARDS). However intravascular oxidation through higher gas exchange is needed for successful clinical applications. In this study, an attempt was made to improve the gas exchange of an intravascular lung assist device by decreasing the level of damage to the blood through the microencapsulation of hemoglobin. The results showed that a hemosome 0.8 microm in diameter could be produced by microencapsulating the hemoglobin extracted from fresh bovine blood with the phospholipids extracted from egg yolk. The oxygen saturation curve of hemosome was S-shaped, which is similar to that found in normal blood, and the P50 was 24 mmHg. The oxygen saturation in the mixed solution of hemosome and blood at a 1:4 (v/v%) ratio was similar to that of normal blood. The gas exchange of the blood-hemosome mixed solution was more effective than whole blood. Therefore, the hemosome solution is expected to improve oxygen transfer. |
| | |
Authors:
|
Gi-Beum Kim; Chul-Un Hong; Jin-Shang Kim; Min-Ho Kim; Hyung-Sub Kang |
Related Documents
:
|
7277515 - Exchange transfusion using g-6-pg deficient or hgb-as blood in icteric neonates. 21322395 - Use of transsplenic injection of agitated saline and heparinized blood for the ultrason... 2506755 - Two hundred intrauterine exchange transfusions in severe blood incompatibilities. 9590495 - Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood ... 9579605 - Flow cytometry with or without cytochemistry for the diagnosis of acute leukemias? 16501565 - Myosin ii functions in actin-bundle turnover in neuronal growth cones. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The International journal of artificial organs Volume: 33 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-07-08 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: Italy |
Other Details:
|
Languages: eng Pagination: 171-8 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University, Jeonju, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Substitutes / chemical synthesis* Cattle Drug Compounding Equipment Design Hemoglobins / chemistry* Membranes, Artificial* Oxidation-Reduction Oxygenators, Membrane* Pulmonary Gas Exchange* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Substitutes; 0/Hemoglobins; 0/Membranes, Artificial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of inflammatory response during on-pump and off-pump coronary artery bypass surgery.
Next Document: Improved management of intradialytic hypotension (IDH) using vitamin E-bonded polysulfone membrane d...