Document Detail

Improvement from pulmonary hyperinflation and bronchial obstruction following sympathomimetics systemically given in infants with broncho-pulmonary diseases.
MedLine Citation:
PMID:  2349817     Owner:  NLM     Status:  MEDLINE    
Functional disorders and efficacy of treatment with a beta-2-agonist salbutamol (Ventolin), 0.225 mg/kg bodyweight, systemically given, were evaluated by infant whole-body plethysmography in 60 infants (64 data sets) with broncho-pulmonary disease belonging to three diagnostic groups: 24 survivors after respiratory distress syndrome, 21 patients with recurrent wheezing, and 15 infants with cystic fibrosis. The values of thoracic gas volume (IGV) and airway resistance (Raw) prior to the drug administration showed a scattered distribution, which was unrelated to the 3 diagnostic groups. Therefore, stratification into 4 functional groups was performed. In 25 tests (22 infants) normal lung function (TGV less than 130% pred., Raw less than 130% pred.); in 16 tests pulmonary hyperinflation (TGV greater than 130% pred., Raw less than 130% pred.); in 10 tests hyperinflation and bronchial obstruction (TGV and Raw greater than 130% pred.); and in 13 tests (12 patients) bronchial obstruction (TGV less than 130% pred; Raw greater than 130% pred.) were found. The response to beta-2-agonists was evaluated by vector analysis (circular statistics) revealing different response groups. With respect to the initial lung function abnormality and due to a stratification into different "response groups", beta adrenoreceptor agonists showed a volume-response (decrease in end-expiratory level) in 63% of infants with pulmonary hyperinflation, a flow response (improvement of airway resistance) in 54% of infants with predominantly bronchial obstruction and a mixed-response (decrease of TGV and Raw) in 70% of infants with mixed functional abnormalities, at least if the drug is given systemically. However, distinction into functional groups and its response to a sympathomimetic agent is only possible when both, changes in TGV and concomitant changes in Raw are accurately assessed.
R Kraemer; M H Schöni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Erkrankungen der Atmungsorgane     Volume:  174     ISSN:  0303-657X     ISO Abbreviation:  Z Erkr Atmungsorgane     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-12     Completed Date:  1990-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503239     Medline TA:  Z Erkr Atmungsorgane     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  85-96     Citation Subset:  IM    
Department of Pediatrics, University of Berne/Switzerland.
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MeSH Terms
Airway Resistance / drug effects*
Albuterol / administration & dosage*
Bronchitis / drug therapy*
Bronchopulmonary Dysplasia / drug therapy*
Cystic Fibrosis / drug therapy*
Hyaline Membrane Disease / drug therapy
Infant, Newborn
Lung Volume Measurements*
Plethysmography, Whole Body
Respiratory Distress Syndrome, Newborn / drug therapy*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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