| Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis. | |
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MedLine Citation:
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PMID: 17938525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AL amyloidosis is a disease in which immunoglobulin L chain is deposited in multiple organs, and the prognosis of cardiac amyloidosis is extremely poor. Although several treatments based on that for multiple myeloma, have been performed, there is no clear evidence that cardiac function is improved. We report a case of AL cardiac amyloidosis with moderate cardiac dysfunction for which we performed autologous peripheral blood stem cell transplantation (auto-PBSCT) in combination with high-dose melphalan therapy. This treatment resulted in significant improvement in cardiac function and good prognosis for about 3.5 years after the diagnosis. Therefore, auto-PBSCT is a possible option as up-front therapy for AL cardiac amyloidosis. |
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Authors:
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Shusuke Yagi; Masashi Akaike; Shuji Ozaki; Chikako Moriya; Kyoko Takeuchi; Tomoko Hara; Mitsunori Fujimura; Yuka Sumitomo; Takashi Iwase; Yasumasa Ikeda; Ken-ichi Aihara; Takehiko Kimura; Takeshi Nishiuchi; Masahiro Abe; Toshio Matsumoto |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-10-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 46 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-10-16 Completed Date: 2007-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1705-10 Citation Subset: IM |
Affiliation:
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Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School. syagi@clin.med.tokushima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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physiopathology,
therapy* Cardiomyopathies / physiopathology, therapy* Combined Modality Therapy Female Heart / physiopathology Humans Melphalan / administration & dosage Middle Aged Peripheral Blood Stem Cell Transplantation* Prognosis |
| Chemical | |
Reg. No./Substance:
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148-82-3/Melphalan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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