Document Detail

Improvement of brain electrical activity during treatment of porcine malignant hyperthermia with dantrolene.
MedLine Citation:
PMID:  8280559     Owner:  NLM     Status:  MEDLINE    
Three months before this study, susceptibility for malignant hyperthermia (MH) had been tested in 15 pigs. In all pigs, MH was triggered by administration of 1% halothane. Brain electrical activity was examined during therapy of MH with and without administration of dantrolene. From the EEG, power densities in selected frequencies and the median frequency of the power spectrum were calculated. Therapy was started when severe respiratory changes were observed (PaCO2 > 10 kPa, mixed venous oxygen tension (PvO2) < 4 kPa). At this time, heart rate exceeded 150 beat min-1, mean arterial pressure (MAP) was less than 60 mm Hg and median frequency was less than 2 Hz. EEG was isoelectric (n = 6) or showed slow polymorphic delta-activity. For therapy, administration of all anaesthetics was terminated, 100% oxygen was delivered and ventilation was increased four-fold. Acidosis was treated by administration of sodium bicarbonate 2-4 mmol litre-1 kg-1. Animals were allocated randomly to one of two groups: group I (control, n = 7) received no dantrolene; group II (n = 8) received dantrolene 2.5 mg kg-1 i.v. All variables were measured over a period of 60 min after therapy: EEG, HR and MAP were recorded continuously and blood-gas tensions, arterial potassium and glucose concentrations and pH were measured every 150 s. In group I (no dantrolene) minor, transient improvements in EEG activity were noted, but all animals died within 15-25 min after the start of therapy. In dantrolene-treated animals, EEG total power and median frequency increased within 5 min.(ABSTRACT TRUNCATED AT 250 WORDS)
E Kochs; W E Hoffman; J Schulte am Esch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  71     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-15     Completed Date:  1994-02-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  881-4     Citation Subset:  IM    
Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, GErmany.
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MeSH Terms
Blood Pressure / drug effects
Brain / physiopathology*
Carbon Dioxide / blood
Dantrolene / therapeutic use*
Electroencephalography / drug effects*
Malignant Hyperthermia / drug therapy*,  etiology,  physiopathology
Oxygen / blood
Partial Pressure
Reg. No./Substance:
124-38-9/Carbon Dioxide; 151-67-7/Halothane; 7261-97-4/Dantrolene; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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