Document Detail

Improvement of bone formation biomarkers after 1-year consumption with milk fortified with eicosapentaenoic acid, docosahexaenoic acid, oleic acid, and selected vitamins.
MedLine Citation:
PMID:  20579524     Owner:  NLM     Status:  MEDLINE    
The hypothesis of this study was that the replacement of regular milk with fortified milk in hyperlipidemic adults for 1 year would improve bone biomarkers. The fortified milk contained eicosapentaenoic acid and docosahexaenoic acid from fish oils, oleic acid, vitamins A, B(6), and E, as well as folic acid. We believe that the fortified milk will improve the blood fatty acid profile and vitamin status in subjects to benefit bone health biomarkers. From the 84 patients who accepted to participate, 11 of these were excluded for the presence of metabolic diseases and 1 was excluded for noncompliance with the protocol. Seventy-two hyperlipidemic patients (35-65 years) were randomly divided between 2 study groups. The supplement group (E; n = 39) consumed 0.5 L/d of fortified milk that contained fish oil, oleic acid, and vitamins. The control group (C; n = 33) consumed 0.5 L/d of semiskimmed milk containing the same amount of total fat. Blood samples were taken at T(0), T(3), T(6), and T(12) months to determine plasma fatty acids, vitamins B(6), E, and 25-hydroxyvitamin D and serum folate, calcium, soluble osteoprotegerin (OPG), soluble receptor activator of NF-kappaB ligand (RANKL), osteocalcin, parathormone, type I collagen carboxy-terminal telopeptide, and malondialdehyde. After 1 year, the E group showed a significant increase in plasma eicosapentaenoic acid (42%), docosahexaenoic acid (60%), vitamin B6 (38%), OPG (18%), RANKL (7%), OPG/RANKL (10%), red blood cell folate (21%), serum folate (53%), calcium (4%), vitamin D (11%), and osteocalcin (22%). Dietary supplementation with the fortified milk drink improved nutritional status and bone formation markers in adult hyperlipidemic patients.
Elena Martin-Bautista; Manuel Muñoz-Torres; Juristo Fonolla; Miguel Quesada; Antonio Poyatos; Eduardo Lopez-Huertas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  30     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Pediatrics, School of Medicine, Granada 18001, Spain.
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MeSH Terms
Biological Markers / blood*
Calcium / blood
Double-Blind Method
Erythrocytes / metabolism
Fatty Acids, Omega-3 / pharmacology*,  therapeutic use
Folic Acid / blood
Food, Fortified
Hyperlipidemias / diet therapy*
Longitudinal Studies
Middle Aged
Oleic Acid / pharmacology*,  therapeutic use
Osteocalcin / blood
Osteogenesis / drug effects*
Osteoprotegerin / blood
RANK Ligand / blood
Time Factors
Vitamin B 6 / blood
Vitamin D / blood
Vitamins / blood,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Osteoprotegerin; 0/RANK Ligand; 0/Vitamins; 104982-03-8/Osteocalcin; 112-80-1/Oleic Acid; 1406-16-2/Vitamin D; 59-30-3/Folic Acid; 7440-70-2/Calcium; 8059-24-3/Vitamin B 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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