| Improvement of blood flow, expression of nitric oxide, and vascular endothelial growth factor by low-energy shockwave therapy in random-pattern skin flap model. | |
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MedLine Citation:
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PMID: 19034081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracorporeal shock wave therapy (ESWT) can improve flap survival, but its mechanism remains unclear. In this study, we aim to investigate whether ESWT can improve blood flow in ischemic skin flaps and the possible mechanism. Cranially based random-pattern flap (3 x 10 cm) model was established, and its ischemic portion was treated with or without ESWT at 0.09 mJ/mm2 with 750 impulses (1.5 Hz), immediately after operation. Survival area, blood flow, vessel distribution, microvessel density, and expression of nitric oxide and vascular endothelial growth factor were evaluated at 1, 3, and 10 days postoperatively. The results showed that blood perfusion, expression of nitric oxide and vascular endothelial growth factor, vasodilatation of pre-existing vessels at early postoperative stage, neovascularization at late stage, and flap survival were all significantly promoted in treatment group. In conclusion, ESWT can improve skin flap surviving rate through enhanced vasodilatation at early postoperative stage and neovascularization at late stage via modulation of angio-active factors expression. |
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Authors:
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Xiaoyu Yan; Bingfang Zeng; Yimin Chai; Congfeng Luo; Xiaolin Li |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of plastic surgery Volume: 61 ISSN: 1536-3708 ISO Abbreviation: Ann Plast Surg Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2009-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 646-53 Citation Subset: IM |
Affiliation:
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Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ischemia / therapy*, ultrasonography Laser-Doppler Flowmetry Male Nitric Oxide / biosynthesis* Rats Rats, Sprague-Dawley Surgical Flaps / blood supply*, physiology* Ultrasonic Therapy* Ultrasonics Vascular Endothelial Growth Factor A / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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