| Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 15220300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic heart failure (CHF) may impair lung gas diffusion, an effect that contributes to exercise limitation. We investigated whether diffusion improvement is a mechanism whereby physical training increases aerobic efficiency in CHF. Patients with CHF (n = 16) were trained (40 min of stationary cycling, 4 times/wk) for 8 wk; similar sedentary patients (n = 15) were used as controls. Training increased lung diffusion (DlCO, +25%), alveolar-capillary conductance (DM, +15%), pulmonary capillary blood volume (VC, +10%), peak exercise O2 uptake (peak VO2, +13%), and VO2 at anaerobic threshold (AT, +20%) and decreased the slope of exercise ventilation to CO2 output (VE/VCO2, -14%). It also improved the flow-mediated brachial artery dilation (BAD, from 4.8 +/- 0.4 to 8.2 +/- 0.4%). These changes were significant compared with baseline and controls. Hemodynamics were obtained in the last 10 patients in each group. Training did not affect hemodynamics at rest and enhanced the increase of cardiac output (+226 vs. +187%) and stroke volume (+59 vs. +49%) and the decrease of pulmonary arteriolar resistance (-28 vs. -13%) at peak exercise. Hemodynamics were unchanged in controls after 8 wk. Increases in DlCO and DM correlated with increases in peak VO2 (r = 0.58, P = 0.019 and r = 0.51, P = 0.04, respectively) and in BAD (r = 0.57, P < 0.021 and r = 0.50, P = 0.04, respectively). After detraining (8 wk), DlCO, DM, VC, peak VO2, VO2 at AT, VE/VCO2 slope, cardiac output, stroke volume, pulmonary arteriolar resistance at peak exercise, and BAD reverted to levels similar to baseline and to levels similar to controls. Results document, for the first time, that training improves DlCO in CHF, and this effect may contribute to enhancement of exercise performance. |
| | |
Authors:
|
Marco Guazzi; Giuseppe Reina; Gabriele Tumminello; Maurizio D Guazzi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-06-25 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 97 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-10-11 Completed Date: 2005-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1866-73 Citation Subset: IM |
Affiliation:
|
Cardiopulmonary Laboratory, Cardiology Division, University of Milan, San Paolo Hospital, Via A. di Rudinì, 8, 20142 Milan, Italy. marco.guazzi@unimi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bicycling Blood Volume Brachial Artery / physiopathology Capillaries / physiopathology Cardiac Output Cardiac Output, Low / physiopathology* Chronic Disease Humans Male Middle Aged Oxygen Consumption Physical Education and Training* Pulmonary Alveoli / physiopathology Pulmonary Circulation Pulmonary Diffusing Capacity* Regional Blood Flow Stroke Volume Vascular Resistance Vasodilation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oscillation mechanics of the human lung periphery in asthma.
Next Document: Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel.