| Improvement and Impairment of Visually Guided Behavior through LTP- and LTD-like Exposure-Based Visual Learning. | |
| | |
MedLine Citation:
|
PMID: 21549600 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cellular studies have focused on long-term potentiation (LTP) and long-term depression (LTD) to understand requirements for persistent changes in synaptic connections [1-3]. Whereas LTP is induced through high-frequency intermittent stimulation, low-frequency stimulation evokes LTD [4]. Because of the ubiquitous efficacy of these protocols, they are considered fundamental mechanisms underlying learning. Here we adapted LTP/LTD-like protocols to visual stimulation to alter human visually guided behavior. In a change-detection task, participants reported luminance changes against distracting orientation changes. Subsequently, they were exposed to passive visual high- or low-frequency stimulation of either the relevant luminance or irrelevant orientation feature. LTP-like high-frequency protocols using luminance improved ability to detect luminance changes, whereas low-frequency LTD-like stimulation impaired performance. In contrast, LTP-like exposure of the irrelevant orientation feature impaired performance, whereas LTD-like orientation stimulation improved it. LTP-like effects were present for 10 days, whereas LTD-like effects lasted for a shorter period of time. Our data demonstrate that instead of electrically stimulating synapses, selective behavioral changes are evoked in humans by using equivalently timed visual stimulation, suggesting that both LTD- and LTP-like protocols control human behavior but that the direction of changes is determined by the feature incorporated into the stimulation protocol. |
| | |
Authors:
|
Christian Beste; Edmund Wascher; Onur Güntürkün; Hubert R Dinse |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
|
Title: Current biology : CB Volume: - ISSN: 1879-0445 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Abteilung Biopsychologie, Institut für Kognitive Neurowissenschaft, Ruhr-Universität Bochum, 44780 Bochum, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila.
Next Document: The requirement for the Dam1 complex is dependent upon the number of kinetochore proteins and microt...