Document Detail

Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment.
MedLine Citation:
PMID:  23162229     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Regulated negative pressure-assisted wound therapy (RNPT) should be regarded as a state-of-the-art technology in wound treatment and the most important physical, nonpharmaceutical, platform technology developed and applied for wound healing in the last two decades. RNPT systems maintain the treated wound's environment as a semi-closed, semi-isolated system applying external physical stimulations to the wound, leading to biological and biochemical effects, with the potential to substantially influence wound-host interactions, and when properly applied may enhance wound healing. RNPT is a simple, safe, and affordable tool that can be utilized in a wide range of acute and chronic conditions, with reduced need for complicated surgical procedures, and antibiotic treatment. This technology has been shown to be effective and safe, saving limbs and lives on a global scale. Regulated, oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) is an innovative technology, whereby supplemental oxygen is concurrently administered with RNPT for their synergistic effect on treatment and prophylaxis of anaerobic wound infection and promotion of wound healing. Understanding the basic science, modes of operation and the associated risks of these technologies through their fundamental clinical mechanisms is the main objective of this review.
Moris Topaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India     Volume:  45     ISSN:  1998-376X     ISO Abbreviation:  Indian J Plast Surg     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2012-11-20     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8405356     Medline TA:  Indian J Plast Surg     Country:  India    
Other Details:
Languages:  eng     Pagination:  291-301     Citation Subset:  -    
Plastic Surgery Unit, Hillel Yaffe Medical Center, Hadera, Department of Chemistry, Bar Ilan University, Ramat Gan, Israel.
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