| Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility. | |
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MedLine Citation:
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PMID: 15818036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular (RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility. We investigated the effects of the inhaled PGI(2) analogs epoprostenol (EPO) and iloprost (ILO) on RV function and myocardial contractility in 9 anesthetized pigs receiving aerosolized EPO (25 and 50 ng.kg(-1).min(-1)) and, consecutively, ILO (60 ng.kg(-1).min(-1)) for 20 min each. We measured pulmonary artery pressure (PAP), RV ejection fraction (RVEF) and RV end-diastolic-volume (RV-EDV), and left ventricular end-systolic pressure-volume-relation (end-systolic elastance, E(es)). EPO and ILO reduced PAP, increased RVEF and reduced RVEDV. E(es) was enhanced during all doses tested, which reached statistical significance during EPO(25 ng) and ILO, but not during EPO(50 ng). PGI(2) aerosol enhances myocardial contractility in healthy pigs, contributing to improve RV function. |
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Authors:
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G Kemming; H Kisch-Wedel; M Flondor; C Hofstetter; W Kreyling; E Thein; F Meisner; S Bruhn; B Zwissler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 37 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-04-08 Completed Date: 2005-07-12 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 9-17 Citation Subset: IM |
Affiliation:
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Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols Animals Blood Pressure / drug effects Blood Volume / drug effects Dose-Response Relationship, Drug Drug Administration Schedule Epoprostenol / administration & dosage*, pharmacology Iloprost / administration & dosage*, pharmacology Myocardial Contraction / drug effects* Stroke Volume / drug effects Swine Vasodilator Agents / administration & dosage*, pharmacology Ventricular Function, Right / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Vasodilator Agents; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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