Document Detail

Improved therapy and outcome for patients with acute myocardial infarction--data of the Berlin Myocardial Infarction Registry from 1999 to 2004.
MedLine Citation:
PMID:  18061689     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Guidelines for treatment of patients with myocardial infarction (MI) have been regularly updated. In addition, a new definition for acute MI has been recently established. The aim of our study was to evaluate development of treatment and effects on patient outcome. METHODS: We prospectively collected data from MI patients who were treated in 22 hospitals in Berlin, Germany, during the years 1999 to 2004. In the study we consecutively included 6080 MI patients presenting with (STEMI, n=4314) and without persistent ST-segment elevation (NSTEMI, n=1766). RESULTS: STEMI and NSTEMI patients showed an increase over time in arterial hypertension, smoking, hypercholesterolaemia, history of congestive heart failure, and renal failure. The application of acute percutaneous coronary intervention increased from 15.3% to 62.3% (p<0.001) for NSTEMI and from 24.7% to 71.8% (p<0.001) for STEMI patients. Concomitant therapy with beta-blockers, ACE inhibitors, statins, GP IIb/IIIa, and aspirin increased in parallel in both groups. The decrease in hospital mortality was more pronounced for NSTEMI (13.5% vs. 4.6%, p<0.001) than with STEMI patients (13.0% vs. 9.4%, p=0.005). CONCLUSIONS: Adherence to guidelines has led to a higher level of hospital care for NSTEMI and STEMI patients. Hospital mortality decreased for both groups, with a greater impact on NSTEMI patients.
Birga Maier; Walter Thimme; Ralph Schoeller; Andreas Fried; Steffen Behrens; Heinz Theres;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-12-03
Journal Detail:
Title:  International journal of cardiology     Volume:  130     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Technische Universitaet, Berlin, Germany.
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MeSH Terms
Aged, 80 and over
Berlin / epidemiology
Databases, Factual / trends*
Hospital Mortality / trends
Middle Aged
Myocardial Infarction / mortality*,  therapy*
Practice Guidelines as Topic / standards
Prospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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