Document Detail


Improved synthesis of phosphatidylserine using bio-based solvents, limonene and p-cymene.
MedLine Citation:
PMID:  25214218     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The bio-based solvents limonene and p-cymene obtained from citrus waste were innovatively employed as the reaction media for enzymatic synthesis of phosphatidylserine. (R)-(+)-Limonene, which is available in large quantities from citrus waste, and its close derivative p-cymene, are promising green solvents. Herein, they were successfully employed as reaction media for enzyme-mediated transphosphatidylation of phosphatidylcholine with L-serine for phosphatidylserine synthesis for the first time. A 95 % yield of phosphatidylserine was achieved after 12 h and the side-reactions (which are the undesirable hydrolysis of phosphatidylcholine and phosphatidylserine) did not happen. This work presents an alternative strategy for preparing phosphatidylserine that possesses obvious advantages over the traditional processes in terms of high efficiency combined with environmental friendliness.
Authors:
Yan-Hong Bi; Zhang-Qun Duan; Wen-Ying Du; Zhao-Yu Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-12
Journal Detail:
Title:  Biotechnology letters     Volume:  -     ISSN:  1573-6776     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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