Document Detail


Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis.
MedLine Citation:
PMID:  12798374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use.
Authors:
Jonathan McConathy; Ronald J Voll; Weiping Yu; Ronald J Crowe; Mark M Goodman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  58     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  657-66     Citation Subset:  IM    
Affiliation:
Department of Radiology, EUH, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Carboxylic Acids / chemical synthesis*,  chemistry,  diagnostic use,  isolation & purification*
Cyclobutanes / chemical synthesis*,  chemistry,  diagnostic use,  isolation & purification*
Humans
Isotope Labeling / methods*
Neoplasms / metabolism,  radionuclide imaging
Quality Control
Radiopharmaceuticals / chemical synthesis,  chemistry,  diagnostic use,  isolation & purification
Tomography, Emission-Computed / methods
Chemical
Reg. No./Substance:
0/1-amino-3-fluorocyclobutane-1-carboxylic acid; 0/Carboxylic Acids; 0/Cyclobutanes; 0/Radiopharmaceuticals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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