| Improved survival time with combined early blood transfusion and fluid administration in uncontrolled hemorrhagic shock in rats. | |
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MedLine Citation:
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PMID: 20154543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test whether early blood administration combined with crystalloid solution infusion may prolong survival in a clinically relevant model of ongoing uncontrolled life-threatening hemorrhage. METHODS: Light anesthesia was induced with halothane in 24 rats, and spontaneous breathing was maintained. Uncontrolled hemorrhagic shock was induced by withdrawal of blood at 2.5 mL/100 g over a 15-minute period, followed by 75% tail amputation. At 10 minutes after tail cutting, rats were randomized into four groups (n = 6 each): group 1, receiving 3 mL of shed blood for 5 minutes followed by 9 mL of lactated Ringer's (LR) solution for 15 minutes; group 2, receiving 9 mL of LR solution for 15 minutes followed by 3 mL of shed blood for 5 minutes; group 3, receiving 9 mL of LR solution only for 15 minutes; group 4, receiving neither of shed blood nor LR solution. Rats were then observed until death or a maximum of 180 minutes. RESULT: Mean survival time was 138 +/- 30 minutes, 108 +/- 22 minutes, 79 +/- 13 minutes, and 55 +/- 18 minutes for groups 1, 2, 3, and 4, respectively (p < 0.05 among the four groups). Additional blood loss from the tail stump did not differ significantly between the three treatment groups. CONCLUSIONS: In a model of uncontrolled hemorrhagic shock in rats, a resuscitation regimen using crystalloids agent alone is not ideal, and even a brief delay in blood administration worsens survival. Early blood administration combined with crystalloid solution infusion seems ideal. |
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Authors:
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Akira Takasu; Yusuke Minagawa; Satoshi Ando; Yorihiro Yamamoto; Toshihisa Sakamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 68 ISSN: 1529-8809 ISO Abbreviation: J Trauma Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-04-01 Revised Date: 2011-09-19 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 312-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Traumatology and Critical Care Medicine, National Defense Medical College, Saitama, Japan. atakasu@ndmc.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Blood Transfusion* Disease Models, Animal Fluid Therapy / methods* Heart Rate Hematocrit Infusions, Intravenous Isotonic Solutions / administration & dosage Male Rats Rats, Sprague-Dawley Saline Solution, Hypertonic / administration & dosage Shock, Hemorrhagic / mortality*, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 0/Saline Solution, Hypertonic; 8022-63-7/Ringer's lactate |
| Comments/Corrections | |
Comment In:
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J Trauma. 2011 Jun;70(6):1580-1
[PMID:
21818003
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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