Document Detail


Improved survival from lung cancer in British Columbia compared to Scotland-are different treatment rates the whole story?
MedLine Citation:
PMID:  19036470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To explore possible causes of the poor survival of Scottish lung cancer patients, a retrospective registry-based audit was conducted comparing demography, treatment and survival of 3833 Scottish patients and 2073 from British Columbia (BC). Patients from Scotland were older, had a lower rate of pathological confirmation (74% vs 89%, p<0.001), but more squamous (51% vs 31%, p<0.001) or small cell (SCLC) (18% vs 15%, p=0.005) cancers. Fewer Scottish patients received any treatment (57% vs 66%, p<0.001) or treatment aimed at cure (14% vs 26%, p<0.001). Survival was lower in Scotland (median 3.6 months vs 7.3 months; 5% vs 10% 5-year overall survival, p<0.001), irrespective of treatment intent (potentially curative treatment median survival 20.9 months vs 34.0 months, 5-year overall survival 29% vs 34%, p<0.001; palliative treatment 5.0 months vs 6.3 months (p<0.001) and no treatment 1.4 months vs 2.5 months (p<0.001)). With treatment intent included in a multivariate analysis, the hazard ratio for death for lung cancer patients in Scotland compared to British Columbia was 1.5. Relative survival was higher in BC (38% at 1 year and 12% at 5 years vs 22% and 6%, p<0.001), indicating that life expectancy differences between the two countries was not the explanation. Reduced levels of treatment could only partially explain survival differences and other unknown factors related to lifestyle differences such as diet and smoking, co-morbid diseases, population genetics or cancer biology, may be important and warrant further exploration.
Authors:
Sara C Erridge; Brian Murray; Linda Williams; David Brewster; Roger Black; Allan Price; Nevin Murray; Finbarr Sheehan
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-25
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  64     ISSN:  1872-8332     ISO Abbreviation:  Lung Cancer     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  358-66     Citation Subset:  IM    
Affiliation:
Edinburgh Cancer Centre, Western General Hospital, Edinburgh, United Kingdom; University of Edinburgh, Edinburgh, United Kingdom. serridge@staffmail.ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Antineoplastic Protocols*
British Columbia
Carcinoma, Squamous Cell / epidemiology,  mortality,  therapy*
Female
Humans
Life Expectancy
Lung Neoplasms / epidemiology,  mortality,  therapy*
Male
Middle Aged
Registries
Retrospective Studies
Scotland
Small Cell Lung Carcinoma / epidemiology,  mortality,  therapy*
Smoking
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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