| Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. | |
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MedLine Citation:
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PMID: 2993147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term follow-up (median: 37 months; range: 19 to 68) of the 116 patients (56 sclerotherapy, 60 control group) entered into a controlled trial of endoscopic variceal sclerotherapy has shown a total of 18 deaths in the sclerotherapy group, including five from variceal bleeding compared with 32 deaths in the control group (p less than 0.01), of which 25 were from variceal hemorrhage (p less than 0.001). Survival as assessed by cumulative life analysis was significantly better in those treated by sclerotherapy (p less than 0.001). Both the cumulative proportion of patients rebleeding and the total number of episodes of variceal hemorrhage were also significantly less in the sclerotherapy group (p less than 0.01). Recurrence of varices was observed in 27 of 45 patients in whom variceal obliteration was initially observed at a median of 11 months (range: 2 to 27) later, although in only 12 of these did bleeding recur and was the cause of death in one. |
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Authors:
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D Westaby; B R Macdougall; R Williams |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 5 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1985 Sep-Oct |
Date Detail:
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Created Date: 1985-10-21 Completed Date: 1985-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 827-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Carcinoma, Hepatocellular / complications Clinical Trials as Topic Esophageal and Gastric Varices / mortality, therapy* Female Follow-Up Studies Gastrointestinal Hemorrhage / mortality, therapy* Hepatitis, Chronic / complications Humans Injections Liver Cirrhosis, Alcoholic / complications Liver Cirrhosis, Biliary / complications Liver Neoplasms / complications Male Middle Aged Recurrence Sclerosing Solutions / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Sclerosing Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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